ISSN:
1432-2013
Keywords:
Frog heart
;
i K1
;
Cs ions
;
acetylcholine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract 1. In frog atrium, Cs ions block both the inward rectifieri K1 and the carbachol induced K currenti Cch. 2. Bothi K1 andi Cch display a high affinity for Cs with a K0.5 of 4×10−5 M fori k1 and of 8×10−5 M fori Cch atV=−50 mV. 3. Block of bothi K1 andi Cch is strongly voltage dependent. When fitted by the block model of Woodhull (1973), δ is 〉1 for the two currents. 4. From these similarities, action of Cch on frog atrium K permeability could be interpreted as a modification ofi K1.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00580264
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