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  • 1
    Electronic Resource
    Electronic Resource
    Direct transfer of a lysosomal enzyme from lymphoid cells to deficient fibroblasts (1981)
    [s.l.] : Nature Publishing Group
    Nature 291 (1981), S. 244-247 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Monolayer cultures of -glucuronidase-deficient fibroblasts (GM 151 cells) contained no detectable enzyme activity, even at high cell density. After co-culture with lymphocytes, -glucuronidase was detected in all the GM 151 cells examined (Fig. la). Direct measurement of enzyme activity acquired by ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/291244a0
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Direct enzyme transfer from lymphocytes is specific (1983)
    [s.l.] : Nature Publishing Group
    Nature 306 (1983), S. 75-77 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Concanavalin A (Con A)-transformed mouse spleen lymphocytes were co-cultured for 24 h, as previously described6, with cells from several human fibroblast lines each genetically deficient in a different enzyme. The lymphocytes were removed and enzyme activities were measured in extracts of the ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/306075a0
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  • 3
    Electronic Resource
    Electronic Resource
    The channel cell of the terrestrial slug Ariolimax columbianus (Stylommatophora, Arionidae) (1984)
    Springer
    Cell & tissue research 235 (1984), S. 143-151 
    Details
    ISSN: 1432-0878
    Keywords: Channel cell ; Slug ; Particle transport
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Studies were carried out to identify the route by which macromolecules and large volumes of fluid traverse the skin of terrestrial gastropods. Electron micrographs of the skin of the banana slug Ariolimax columbianus demonstrated that carbon particles can enter large, specialized cells and pass thence to the exterior. These cells, which are termed channel cells, range up to 500 μm in length; they reach from the external surface of the skin to deep within the subepithelial interstitium. At the light-microscope level they show a large central channel or reservoir apparently filled with homogeneous fluid; after injection of ink into the body cavity this central channel becomes ink-filled. Electron micrographs show cisternae of the smooth endoplasmic reticulum, opening from the cell surface and occasionally traversing the entire cytoplasmic layer. The neurohormone arginine vasotocin stimulates fluid and particle movement through the channel cell; this response is inhibited by norepinephrine. Fluid output is dependent on the presence of a transwall hydrostatic pressure gradient of about 7 torr or above, as well as on activation of the channel cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00213734
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  • 4
    Electronic Resource
    Electronic Resource
    Effects of mitogenic stimulation of lymphocytes on lysosomal enzyme activity (1983)
    New York, NY [u.a.] : Wiley-Blackwell
    Cell Biochemistry and Function 1 (1983), S. 103-108 
    Details
    ISSN: 0263-6484
    Keywords: Blood cells ; lysosomal enzymes ; lymphocytes ; mitogenic stimulation ; Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Medicine
    Notes: Changes in the activities of several lysosomal enzymes were studied during transformation of mouse spleen cells in vitro. The activity of β-glucuronidase increased during culture in the presence of T or B-cell mitogens, and lymphoblasts contained higher levels of activity than did small, non-transformed lymphocytes. Moreover, lymphoblasts in well-transformed cultures had higher activities than those in poorly-transformed cultures. The activities of other lysosomal enzymes (N-acetyl-β-glucosaminidase, α-mannosidase, β-glucosidase) also increased during mitogenic stimulation, but each at different rates, although aryl sulphatase was unaffected. Such differences may be of importance when lymphocytes are used for diagnosis of inherited lysosomal deficiency diseases.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cbf.290010211
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