ISSN:
0006-3525
Keywords:
Chemistry
;
Polymer and Materials Science
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
An nmr spectral comparison of a model cyclic pentapeptide cyclo(Gly-Pro-Gly-D-Phe-Pro) with an analogous pseudopeptide has been made. The pseudopeptide contains a ψ[CH2S] amide bond replacement at the only amide linkage that, in the model, is not involved in an intramolecular hydrogen bond. Both proton and carbon-13 nmr spectral evidence confirms the retention of β- and γ-turns in the pseudopeptide in chloroform. Characteristic chemical shifts, temperature dependence, and glycine α-resonances support this interpretation. However, evidence of a more flexible conformation involving cis-trans proline isomerism is seen on addition of dimethylsulfoxide.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bip.360220123
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