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  • 1
    Digitale Medien
    Digitale Medien
    PLASMA PROPRANOLOL CONCENTRATION IN PATIENTS WITH ANGINA AND ACUTE MYOCARDIAL INFARCTION (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 3 (1976), S. 0 
    Details
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 1. Plasma levels of propranolol were measured fluorometrically in patients with angina pectoris and in patients admitted to the Coronary Care Unit with acute myocardial infarction.2. In thirty patients with stable angina pectoris, plasma propranolol levels varied almost linearly with doses between 10 and 120 mg during 6-hourly chronic oral administration. Plasma levels greater than 100 ng/ml produced 70–80% reduction in the tachycardia induced by strenous exercise on a treadmill.3. In nineteen patients with acute myocardial infarction given oral propranolol, 20 mg 6-hourly, peak as well as trough plasma levels of the drug increased progressively but remained below 100 ng/ml in all except two patients during the first 24 h after their admission to the Coronary Care Unit.4. The data suggest that the use of low and fixed doses of propranolol may not produce adequate plasma levels or significant β-adrenoceptor blockade in the early stages of acute myocardial infarction in man.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1681.1976.tb00606.x
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  • 2
    Digitale Medien
    Digitale Medien
    EFFECTS OF AMIODARONE AND L8040, NOVEL ANTIANGINAL AND ANTIARRHYTHIC DRUGS, ON CARDIAC AND CORONARY HAEMODYNAMICS AND ON CARDIAC INTRACELLULAR POTENTIALS (1976)
    Oxford, UK : Blackwell Publishing Ltd
    Clinical and experimental pharmacology and physiology 3 (1976), S. 0 
    Details
    ISSN: 1440-1681
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: 1. The effects on the coronary and systemic haemodynamics of intravenous and intracoronary injections of two benzfuran derivatives, amiodarone and its brominated analogue (L8040), were studied in open-chest anaesthetized dogs. The effects of L8040 on cardiac intracellular potentials after 6 weeks of 20 mg/kg intraperitoneal injections in rabbits were also investigated.2. Both compounds produced dose-related and quantitatively similar decreases in coronary vascular resistance following their intracoronary administration; threshold effects occurred with about 0.25 mg of each drug and maximal effects with 4 mg. Larger intracoronary doses produced measurable systemic effects.3. Intravenous injections of amiodarone and L8040 (2·5·10 mg/kg) produced dose-related decreases in heart rate and aortic pressure with a fall in total peripheral resistance. The left ventricular output was either unaffected or increased with a consistent augmentation in stroke volume.4. The bradycardia produced by both drugs was associated with prolongation of the P–R interval of the electrocardiogram with no significant effect on the QRS duration or the Q–T interval.5. Each drug produced a decrease in the total peripheral vascular resistance with no change in left ventricular end diastolic pressure except after 10 mg/kg doses which led to an increase in this parameter.6. Cardiac contractile force and peak LV dp/dt were reduced by both drugs in a dose-related manner.7. Chronic intraperitoneal administration of L8040 in rabbits caused a prolongation of the duration of the atrial and ventricular intracellular potential without an effect on the maximal rate of depolarization.8. The effects of amiodarone or L8040 on the coronary circulation and arterial pressure may be attributed to their vasodilator properties but their depressant actions on cardiac contractile force and peak LV dp/dt with an increase in left ventricular end diastolic pressure at high doses, also suggest intrinsic negative inotropic propensity for both compounds.9. It is concluded that the overall effects on coronary and systemic haemodynamics of amiodarone and its brominated analogue are likely to permit a favourable influence on the balance of oxygen supply and demand in myocardial ischaemia; in addition, their actions on sinoatrial and atrio-ventricular conduction as well as those on cardiac repolarization suggest potential antiarrhythmic properties which merit investigation.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1440-1681.1976.tb00620.x
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  • 3
    Digitale Medien
    Digitale Medien
    Trapping of labile cobalt(III) complexes. Characterization of the perchloratopentaamminecobalt(III) ion (1975)
    s.l. : American Chemical Society
    Inorganic chemistry 14 (1975), S. 2864-2865 
    Details
    ISSN: 1520-510X
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/ic50153a059
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  • 4
    Digitale Medien
    Digitale Medien
    Synthetic polypeptide antigens of defined geometry (1977)
    s.l. : American Chemical Society
    Journal of the American Chemical Society 99 (1977), S. 8491-8498 
    Details
    ISSN: 1520-5126
    Quelle: ACS Legacy Archives
    Thema: Chemie und Pharmazie
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1021/ja00468a018
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  • 5
    Digitale Medien
    Digitale Medien
    Effect of Moonlight on Insect Activity (1951)
    [s.l.] : Nature Publishing Group
    Nature 167 (1951), S. 853-853 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] In spite of the fact that it is generally believed that other methods of catching are also poor at full moon, in the absence of any real evidence for this there was a distinct probability that the low catches in a light trap might be due to a lowered relative luminosity and hence a lowered ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/167853a0
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  • 6
    Digitale Medien
    Digitale Medien
    Nuclear Division in AmŒbÆ and its Bearing on Classification (1951)
    [s.l.] : Nature Publishing Group
    Nature 167 (1951), S. 582-584 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] IN the past, the order Amoebida Calkins has been divided into families on such characters as the presence of a flagellate stage under certain physiological conditions, their parasitic or free-living nature, the possession of an accessory body called Neben-korper, etc. Such a system is not based on ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/167582a0
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  • 7
    Digitale Medien
    Digitale Medien
    IMF effects on short-period fluctuations at low latitudes (1978)
    [s.l.] : Nature Publishing Group
    Nature 272 (1978), S. 517-518 
    Details
    ISSN: 1476-4687
    Quelle: Nature Archives 1869 - 2009
    Thema: Biologie , Chemie und Pharmazie , Medizin , Allgemeine Naturwissenschaft , Physik
    Notizen: [Auszug] As the variations in the equatorial region are highly time-dependent, pairs of low-latitude and equatorial stations have been chosen for analysis from widely separated longitudinal zones-American zone (Huancayo, Fuquene), African zone (16DIR, lat. 9.6N, long. 41.87?, dip. lat. 0.20, a temporary ...
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1038/272517a0
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  • 8
    Digitale Medien
    Digitale Medien
    Haematological parameters of an air-breathing mud eel, Amphipnous cuchia (Ham.) (Amphipnoidae; Pisces) (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of fish biology 10 (1977), S. 0 
    Details
    ISSN: 1095-8649
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Biologie
    Notizen: Haemoglobin concentrations, haematocrit values, red blood cell counts, red blood cell diameter, erythrocyte sedimentation rate and plasma haemoglobin concentration were measured on the air-breathing mud eel Amphipnous cuchia.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1095-8649.1977.tb04089.x
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  • 9
    Digitale Medien
    Digitale Medien
    Altered Enzyme Release by Virus Infected Mouse Salivary Glands (1977)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of oral pathology & medicine 6 (1977), S. 0 
    Details
    ISSN: 1600-0714
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract The rates of release of salivary amylase and esterase from normal and polyoma virus infected mouse submandibular glands were measured in a continuous flow perifusion system. Following stimulation by epinephrine, the rate of release of esterase by the infected glands was significantly greater than that from control glands. The rate of amylase release, while greater from infected glands, was not significantly different. The total enzyme contents from infected and control tissues were similar. Cyclic GMP was found to be higher in the infected glands than the control glands, suggesting one possible mechanism for the higher rates of enzyme release by infected tissues.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1600-0714.1977.tb01642.x
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  • 10
    Digitale Medien
    Digitale Medien
    STUDIES ON THE PREPARATION AND NUTRIENT COMPOSITION OF BULGUR FROM TRITICALE (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of food science 44 (1979), S. 0 
    Details
    ISSN: 1750-3841
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Land- und Forstwirtschaft, Gartenbau, Fischereiwirtschaft, Hauswirtschaft , Werkstoffwissenschaften, Fertigungsverfahren, Fertigung
    Notizen: Bulgur of acceptable quality was prepared from two commercially available cultivars of triticale by boiling 10 min and cooking for 3 min or 10 min at 15 psi and 120°C. Moisture contents of 32-41% were needed to achieve a desirable level of gelatinization of starch. Compared to triticale whole meal, bulgur had almost similar amounts of protein, amino acids and gross energy but lower amounts of crude fat, thiamine, riboflavin, folic acid, vitamin E, calcium, iron, copper, phosphorus, manganese, zinc, potassium, sodium and magnesium.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1365-2621.1979.tb03809.x
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