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  • 1
    Electronic Resource
    Electronic Resource
    In vitro culture of human prostatic tissue (1977)
    Springer
    Urological research 5 (1977), S. 207-210 
    Details
    ISSN: 1434-0879
    Keywords: Cell culture ; Prostate ; Collagenase ; Epithelial
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A procedure is described which yields a significant percentage of long-term mixed cell cultures of human prostatic tissue. Attempts were made to suppress the proliferation of stromal fibroblasts and to characterize the cultured cells as those of prostatic origin. The problems associated with establishing epithelial cell lines are discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00263737
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  • 2
    Electronic Resource
    Electronic Resource
    Nitrate reductase activity in Paul's scarlet rose suspension cultures and the differential role of nitrate and molybdenum in induction (1978)
    Springer
    Planta 141 (1978), S. 183-189 
    Details
    ISSN: 1432-2048
    Keywords: Antimetabolites ; Cell culture ; Enzyme induction ; Molybdenum ; Nitrate reductase ; Rosa, Paul's Scarlet
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Induction of nitrate reductase (EC 1.6.6.1) activity was measured in Paul's Scarlet rose cell suspensions cultured in media containing nitrate (NO 3 - ) or urea (U) as nitrogen source, and with (+Mo) or without molybdenum (-Mo). There was a lag of 30 min during induction by NO 3 - in +Mo cultures but no lag occurred during induction after adding Mo to NO 3 - -Mo or to U-Mo cultures preincubated with NO 3 - . Actinomycin D, cycloheximide, and puromycin completely blocked induction by NO 3 - , but had no effect on the initial rate of induction by Mo. Cycloheximide and puromycin blocked induction by NO 3 - more quickly than actinomycin D. Induction by NO 3 - appeared to involve mRNA-dependent synthesis of apoprotein followed by rapid activation with molybdenum in intact cells independently of protein synthesis. Nitrate-induced apoprotein appeared less stable than the holoenzyme. When induced by NO 3 - in the absence of Mo, apoprotein concentration was about half the amount of maximally induced nitrate reductase. Cycloheximide stabilised preformed nitrate reductase which disappeared steadily in the presence of puromycin. Apoprotein was not stabilised by either antimetabolite.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00387887
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  • 3
    Electronic Resource
    Electronic Resource
    Nitrate reductase activity and growth in Paul's Scarlet rose suspension cultures in relation to nitrogen source and molybdenum (1976)
    Springer
    Planta 133 (1976), S. 27-34 
    Details
    ISSN: 1432-2048
    Keywords: Rose ; Paul's Scarlet ; Cell culture ; Nitrate reductase ; Molybdenum ; Enzyme induction ; Enzyme assay
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Abstract Growth and nitrate reductase activity were measured in Paul's Scarlet rose cell suspensions, cultured in media purified from molybdenum and containing nitrate or urea as sole nitrogen source with or without added Mo. Urea could replace nitrate to yield 80% of the fresh weight in nitrate medium. Nitrate reductase activities were compared by in vivo and in vitro assays. The latter varied due to inactivation during extraction. Compared with activities in cells in complete NO3 - medium, activity in NO3 --Mo cells was reduced to 30% and, in urea-grown cells, to trace amounts. Increases in nitrate reductase activity were found when NO3 - alone was added to NO3 - or urea+Mo cultures. In NO3 --Mo cultures, Mo alone or with NO3 - caused a similar increase in activity, whereas urea-Mo cultures required both NO3 - and Mo for enzyme induction.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00386002
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  • 4
    Electronic Resource
    Electronic Resource
    A theoretical study of liquid-film spread heights in the calendering of newtonian and power law fluids (1970)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 14 (1970), S. 2771-2784 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The relationship between spread height and upstream reservoir thickness, with power low coefficient as parameter, was obtained analytically. At all values of n studied, the value of r (ratio of spread height to nip width) increases with increasing values of H/ho where H is upstream reservoir thickness and ho is nip width. At higher values of H/ho, the curves of r, versus H/ho tend to “flatten” out, and r approaches an asymptotic value. For example, the asymptotic value of r for Newtonian fluids (power law constant of 1) is 1.226. Asymptotic values of r increase with decreasing values of the power law constant.
    Additional Material: 8 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1970.070141111
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  • 5
    Electronic Resource
    Electronic Resource
    A theoretical study of liquid-film spread heights in the calendering of Newtonian and power law fluids (1975)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 19 (1975), S. 2351-2351 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1975.070190826
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  • 6
    Electronic Resource
    Electronic Resource
    The fracture of epoxy- and elastomer-modified epoxy polymers in bulk and as adhesives (1975)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 19 (1975), S. 2545-2562 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: The fracture behavior of a piperidine/bisphenol A diglycidyl ether (A) resin has been determined in bulk and as an adhesive using the linear elastic fracture methods developed by Mostovoy1. The effect of adding carboxy-terminated butadiene-acrylonitrile (CTBN) elastomer to resin A was investigated. The opening-mode fracture energy () of resin A was 120 to 150 J/m2, and largely attributable to plastic deformation. Fractographic evidence was obtained for plastic flow at the crack tip during crack initiation. Propagation was unstable due to the rate dependence of the plasticity. There were no significant differences in the bulk and adhesive fracture behavior. Addition of 5-15% CTBN to resin A produced minute elastomer particles which increased to ∼4000J/m2 (at 15%). Further CTBN addition resulted in an elastomer-epoxy blend and a decrease in fracture energy. Fractography again indicated that crack initiation involved plastic deformation but that the elastomer had greatly increased the volume in which the deformation occurred. The adhesive fracture of the elastomer-epoxy was found to be strongly dependent on the crack-tip deformation zone size (ryc) in that was a maximum when bond thickness was equal to 2 ryc. At bond thicknesses less than 2 ryc, there was a restraint on the development of the plastic zone resulting in lower values.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1975.070190917
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  • 7
    Electronic Resource
    Electronic Resource
    Effect of implant surface chemistry upon arterial thrombosis (1979)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 13 (1979), S. 517-541 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: A series of poly(α-amino acid)s with controlled chemical variations were investigated in order to assess the effect of different chemical moieties upon arterial thrombosis. The gross implant surface properties ranged from hydrophobic to hydrophilic, ionic and nonionic. The materials were tested by implantation within canine femoral and carotid arteries. Results were compared with the response to the polyurethane Biomer.The changes in implant surface chemistry elicited a range of response that varied from intense thrombosis and rapid vessel occlusion to minimal thrombosis and endothelialization. The results showed that no simple relationship exists between a gross surface property, such as hydrophobicity, and the degree of thrombosis resistance. Some hydropobic and hydrophilic materials were found to have good thrombosis were shown to play and hydrophilic materials were found to have good thrombosis were shown to play an important role in both initial thrombosis and endothelialization. The major difference between materials that progressed to to rapid vessel occlusion and materials that remained patent was the degree of direct leukocyte adherence and spreading on the implant surface prior to extensive platelet aggregation (〈30 min). It was consistent for both hydrophobic and hydrophilic materials that the lack of direct leukocyte adherence to the implant surface was associated with intense thrombosis and rapid vessel occlusion. Conversely, the presence of numerous leukocytes directly adherent to either hydrophobic or hydrophilic surfaces appeared to have a moderating effect upon thrombosis and vessels with these implants remained patent. In instances when thrombosis was nonocclusive, the surfaces of the thrombi became endothelialized, primarily through the transformation of mononuclear leukocytes into endothelial cells. This article includes a hypothetical model representing the sequence of events and alternative pathways occurring at the blood-material interface, with special attention given to the involvement of leukocytes in arterial thrombosis.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820130402
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  • 8
    Electronic Resource
    Electronic Resource
    Application of trans-1,4 polyisoprene in orthopedic and rehabilitation medicine (1971)
    Hoboken, NJ : Wiley-Blackwell
    Journal of Biomedical Materials Research 5 (1971), S. 19-30 
    Details
    ISSN: 0021-9304
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Medicine , Technology
    Notes: Ideally, materials from which splints, braces, casts, and other orthopedic appliances are to be made should be capable of being shaped directly against the patient. They should be simple and quick to use, and require the minimum of special equipment. Appliances made from them should be dimensionally stable in service and acceptable to the patient in terms of comfort, weight, durability, and appearance.Synthetic trans-1,4 polyisoprene, prepared with a Ziegler catalyst system, is such a material. It crystallizes at temperatures below 130°F; it is a hard semi-rigid rubber at room temperature; and its compounds can be molded directly against the skin without discomfort. Laboratory tests show that molded shape and strength can be maintained even under stress at temperatures up to about 120°F, and service performance fully supports the results of laboratory testing.This paper describes the properties of trans-1,4 polyisoprene that make the polymer suitable for many orthopedic appliances, and includes examples of its uses in hospitals and rehabilitation institutions. Special attention is given to describing a recently developed technique for the making of artificial limb sockets using trans-1,4 Polyisoprene.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jbm.820050205
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  • 9
    Electronic Resource
    Electronic Resource
    NMR and chemistry, by J. W. Akitt, Chapman and Hall, London, 1973. pp. ix + 182. £1.90 (1973)
    Chichester : Wiley-Blackwell
    Organic Magnetic Resonance 5 (1973), S. A6 
    Details
    ISSN: 0030-4921
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/mrc.1270050712
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  • 10
    Electronic Resource
    Electronic Resource
    The mass spectra of methoxycycloalkanes and methoxymethoxycycloalkanes (1973)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 7 (1973), S. 781-783 
    Details
    ISSN: 0030-493X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: Mass spectra of methoxycycloalkanes (CH3OR, R = C5 to C8) and of methoxymethoxycycloalkanes (CH3OCH2OR, R = C5 to C8, C12) have been compared with each other and with spectra of some steroidal analogues. It is concluded that the different fragmentation occurring in dimethoxymethane indicates decomposition before randomisation of excess energy.
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/oms.1210070703
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