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  • 1975-1979  (2)
  • 1970-1974  (1)
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  • 1
    Digitale Medien
    Digitale Medien
    MASS FRAGMENTOGRAPHIC ASSAY OF HOMOVANILLIC ACID IN BRAIN TISSUE (1973)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 20 (1973), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: Abstract— Available methods for the determination of homovanillic acid (HVA) are based on fluorimetric measurements. The present method uses gas chromatography-mass spectrometry with the aid of deuterium labelled HVA methyl ester as a carrier and internal standard. Quantitation is achieved by comparing intensities of the molecular ion (= base peak) of the protium (H) and deuterium (D) forms of the methyl ester heptafluorobutyric derivatives of HVA. A standard curve is constructed by measuring mixtures of known amounts of protium and deuterium derivatives and plotting peak height ratios H/D on the ordinate and ratios of amounts H/D on the abscissa. Analysis of ten individual mouse brains gave a mean value of 1·36 nmole/g brain tissue with a standard deviation of ±9 per cent. Chlorpromazine elevates, whereas pargyline reduces the level of HVA in brain markedly. The described procedure offers advantages because of the greatly increased specificity and sensitivity permitting analyses in discrete brain areas.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1973.tb00033.x
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  • 2
    Digitale Medien
    Digitale Medien
    A COMPARISON BETWEEN FLUOROMETRIC AND MASS FRAGMENTOGRAPHIC DETERMINATIONS OF HOMOVANILLIC ACID AND 5-HYDROXYINDOLEACETIC ACID IN HUMAN CEREBROSPINAL FLUID (1978)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 31 (1978), S. 0 
    Details
    ISSN: 1471-4159
    Quelle: Blackwell Publishing Journal Backfiles 1879-2005
    Thema: Medizin
    Notizen: HVA and 5-HIAA in human cerebrospinal fluid were quantitatively determined by both fluorometry and mass fragmentography. The homovanillic acid values obtained by fluorometry were significantly lower than those obtained by mass fragmentography (P 〈 0.05). The correlation coefficient between values for HVA obtained by the two methods was high, r= 0.90. For 5-HIAA the concentrations obtained by the two methods were not significantly different while the correlation coefficient was lower, r= 0.55.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1111/j.1471-4159.1978.tb07833.x
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  • 3
    Digitale Medien
    Digitale Medien
    Analysis of tyrosine and deuterium labelled tyrosine in tissues and body fluids (1979)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 6 (1979), S. 392-395 
    Details
    ISSN: 0306-042X
    Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy
    Quelle: Wiley InterScience Backfile Collection 1832-2000
    Thema: Chemie und Pharmazie
    Notizen: A gas chromatographic mass spectrometric method has been developed to determine tyrosine and deuterium labelled tyrosine in biological samples using α-methyltyrosine (α-Me Ty) or m-hydroxyphenylalanine as internal standards. With the latter standard both labelled and unlabelled tyrosine as well as α-Me Ty can be determined simultaneously, in for example human blood, following administration of α-Me Ty to inhibit catecholamine synthesis. After isolation of the amino acids on an ion exchange column (Amberlite IR 120) the butyl ester pentafluoropropionyl derivatives were prepared. In human plasma the precision of the method was determined at a level of 80 nmol tyrosine ml-1 and found to be ±5% (coefficient of variation, n = 10).
    Zusätzliches Material: 4 Ill.
    Materialart: Digitale Medien
    URL: http://dx.doi.org/10.1002/bms.1200060905
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