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  • 1975-1979  (3)
  • 1965-1969  (1)
  • Physics  (2)
  • Gastric mucosal barrier-shock  (1)
  • Gastric ulcer, pathogenesis  (1)
  • Action Programme
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 345 (1977), S. 187-192 
    ISSN: 1435-2451
    Keywords: Gastric ulcer, pathogenesis ; Duodenal ulcer, pathogenesis ; Ulcus duodeni et ventriculi ; Pathogenese
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: ZusammenfaBung „Wer behauptet, das ideale Verfahren zur Behandlung des Magengeschwürs gefunden zu haben, muB als unbescheiden gelten.” Dieser Satz von Schnitzler (1914) gilt im Prinzip bis heute. Pathogenese und operative Verfahren sind nicht kongruent. Es mangelt noch am schlüBigen Konzept der Pathogenese. In kleinen Schritten werden weitere pathogenetische Faktoren und Fakten bekannt, so u. a. für das Ulcus duodeni lokal wirksame chemische Noxen (z. B. Propionitril) für das Ulcus ventriculi der Reflux von Duodenalsaft (z. B. Lysolecithin), der die Schleimhautbarriere vom Magen zu korrodieren vermag. Die derzeit bekannten pathogenetischen Mechanismen werden im einzelnen für die üblichen Geschwürslokalisationen dargestellt.
    Notes: Summary “Anyone who claims to have discovered the ideal procedure in the treatment of gastric ulcer, should be considered immodest.” These words by Schnitzler (1914) are in principle still valid. The pathogenesis and operative procedure are not identical. There is still no conclusive proof of the pathogenesis. The disclosure of other pathogenetic factors and facts is gradual. Locally active chemical noxae (e.g., propionitril) are responsible for the development of duodenal ulcer. Gastric ulcer is caused by the reflux of duodenal juice (e.g., lysolecithin, which is capable of corroding the mucosal barrier of the stomach. The current pathogenetic mechanisms of ulcer of the usual locations are specified.
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    Springer
    Langenbeck's archives of surgery 344 (1977), S. 141-155 
    ISSN: 1435-2451
    Keywords: Stress ulcer ; Acute gastric mucosal lesion (AGML) ; Gastric mucosal barrier-shock
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Das Stressulcus ist die akute Schleimhautläsion des oberen Intestinaltraktes, die im Rahmen einer Erkrankung oder deren Behandlung innerhalb von wenigen Tagen bei vorher magengesunden Patienten auftreten kann. Gefährdet sind Patienten mit großen Operationen, Verbrennungen und verschiedenen Formen des Schocks. Begünstigend wirken Komplikationen, wie respiratorische Insuffizienz, paralytischer Ileus und Infektionen. Das Durchschnittsalter beträgt 53 Jahre, Männer sind häufiger betroffen. Häufigster Manifestationsort ist der proximale Magen; seltener sind Duodenum und terminaler Oesophagus beteiligt. Makroskopisch finden sich meist multiple Erosionen und flächenhafte Ulcerationen, im Duodenum überwiegen die solitären Ulcera. Pathogenetisch sind im wesentlichen drei Faktoren beteiligt, die Salzsäure, eine schockbedingte Störung der Schleimhautmikrozirkulation und ein duodeno-gastraler Reflux von Gallensäuren und Lysolecithin. Häufigstes Symptom ist die Blutung, doch über 50% der Stressulcera verlaufen inapparent. 60–70% der Stressulcera kommen unter konservativen Maßnahmen zur Ausheilung. Unter den operativen Verfahren dominiert die Vagotomie in Kombination mit Umstechung oder Resektion. Zur Prophylaxe dienen eine Vermeidung von Schockzuständen und respiratorischer Insuffizienz, Magensaftdauerableitung, frühe orale Ernährung und intragastrale Applikation von Antacida und Cholestyramin.
    Notes: Summary Stress ulcer means an acute mucosal lesion of the upper gastrointestinal tract in sick patients, who have not had gastroduodenal ulcer before. Most often stress ulcers follow big operations, burns and different types of shock. Complications as respiratory insufficiency, paralytic ileus or infections favor the ulcer formation. The average age is 53 years, males are more often affected. The main localisation is the proximal stomach, less frequently the lesions are located in the duodenum and terminal oesophagus. The macroscopic type is an erosion or a superficial ulceration, a solitary ulcer is typically situated in the duodenum. From the view of pathogenesis three factors are mainly involved: hydrochlorid acid, a disturbance of microcirculation due to shock and a duodenogastric reflux of bile acids and lysolecithin. Most frequent symptom is upper gastrointestinal bleeding, but more than 50% are symptomless. Medical treatment is successful in 60–70%. The surgical treatment of choise is vagotomy in combination with circular sature or resection. Prevention of shock or respiratory insufficiency, permanent gastric suction, early food administration and intragastral application of antacids and cholestyramin are the essentials of stress ulcer prophylaxis.
    Type of Medium: Electronic Resource
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  • 3
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Journal of Polymer Science Part A-2: Polymer Physics 5 (1967), S. 555-568 
    ISSN: 0449-2978
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Notes: A simple differential, isothermal calorimeter has been built to study the thermodynamics of interactions associated with a variety of polymer solution processes. The calorimeter is readily operated at temperatures ranging from ambient to about 200°C., temperature adjustments are rapid, and the apparatus is rugged enough to permit application to commercial process studies. Though less sensitive than microcalorimeters, it represents an attractive combination of satisfactory accuracy, speed, and flexibility of operation. The operation of the calorimeter is demonstrated by measurements of the heat of solution of sodium chloride in water and the heats of solution of various polyolefins in Tetralin and α-chloronaphthalene. The latter tend to confirm the presence of polymer aggregates in chloronaphthalene solutions below the thermodynamic melting temperature of the polymer.
    Additional Material: 5 Ill.
    Type of Medium: Electronic Resource
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  • 4
    Electronic Resource
    Electronic Resource
    New York : Wiley-Blackwell
    Journal of Polymer Science: Polymer Physics Edition 17 (1979), S. 1269-1273 
    ISSN: 0098-1273
    Keywords: Physics ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Physics
    Additional Material: 2 Tab.
    Type of Medium: Electronic Resource
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