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  • 1975-1979  (2)
  • 1965-1969
  • Analytical Chemistry and Spectroscopy  (1)
  • Choleresis  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Effect of nafenopin (SU-13,437) on liver function (1975)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 290 (1975), S. 221-234 
    Details
    ISSN: 1432-1912
    Keywords: Biliary Excretion ; Choleresis ; Nafenopin Enterohepatic Circulation ; Pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Administration of nafenopin (SU-13-437) to male rats for two days leads to a doubling of bile production and a 50% increase in liver weight. These two effects have been shown not to be directly interrelated. A marked decrease in biliary bile salt concentration suggests that the bile salt independent flow is stimulated. The extra bile produced is probably of canalicular origin since bile to plasma concentration ratios of erythritol are unchanged. At least three polar metabolites of nafenopin have been observed in rat bile. Obervations in rats with partial biliary fistulas indicate that the drug and its metabolites undergo extensive enterohepatic circulation. Our studies support the view that much of the enhanced bile flow is associated with the presence of nafenopin and/or its metabolites within the hepatobiliary system. However, the response is too extensive to be explained merely by osmotic choleresis. Induced structural changes in the liver may also account for some of this effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00510552
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    A therotical basis for the “solvent effect” (1978)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 1 (1978), S. 275-276 
    Details
    ISSN: 0935-6304
    Keywords: Gas Chromatography ; Capillary ; Splitless injection ; Theoretical basis for reconcetration by solvent effects ; Guidelines for an effective solvent effect, in literature citation ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240010513
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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