ISSN:
1432-0533
Keywords:
Lissencephaly
;
Pachygyria
;
Neuronal Migration
;
Laminar Necrosis
;
Hypoxia
;
Perfusion Failure
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The architectonic features of abnormal cerebral cortex in a brain with lissencephaly and pachygyria suggest than neuronal migration was interrupted by cortical and subcortical laminar necrosis in the fourth fetal month. The severest cortical abnormality lies in the distal perfusion fields of the major cerebral arteries, while the normal areas are located in the proximal perfusion fields. These architectonic and topographic features suggest that intra-uterine hypoxia or perfusion failure may be a pathogenetic mechanism leading to lissencephaly and pachygyria.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00696881
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