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  • 1975-1979  (4)
  • 1950-1954
  • Rotation  (2)
  • ATPase  (1)
  • Autoradiography  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Apomorphine-induced rotation in normal rats and interaction with unilateral caudate lesions (1975)
    Springer
    Psychopharmacology 40 (1975), S. 329-334 
    Details
    ISSN: 1432-2072
    Keywords: Apomorphine ; Rotation ; Caudate Lesions
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Apomorphine (i.p.) induced rotational behavior (i.e. circling) in normal unoperated rats. This rotation increased with increasing dose up to 10.0 mg/kg, after which the dose-response curve appeared to plateau. Although there was large variability among rats, rotation for each rat was consistent in both direction and magnitude from week to week. Rotation was not antagonized by alpha-methyl-para-tyrosine. When rats with unilateral lesions of the caudate nucleus were tested with apomorphine, postoperative rotation was significantly influenced by the direction of preoperative rotation; rats rotated more postoperatively if the lesion was made ipsilateral rather than contralateral to their preoperative direction of rotation. These results suggest that there is a bilateral asymmetry of dopaminergic receptors in the nigro-striatal pathways of normal rats.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421471
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Drug-induced rotation in rats without lesions: Behavioral and neurochemical indices of a normal asymmetry in nigro-striatal function (1976)
    Springer
    Psychopharmacology 47 (1976), S. 249-260 
    Details
    ISSN: 1432-2072
    Keywords: Rotation ; d-Amphetamine ; Apomorphine ; Scopolamine ; L-Dopa ; Haloperidol
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Normal unoperated rats were tested for rotation (i.e., circling behavior) in a spherical “rotometer” and dose-response relationships were generated using d-amphetamine, apomorphine, L-Dopa, haloperidol, and scopolamine. The rotation induced by amphetamine was significantly antagonized by alphamethyl-p-tyrosine and haloperidol, but not by diethyl-dithiocarbamate. The rotation elicited by apomorphine was unaffected by alpha-methyl-p-tyrosine. Rotation was not necessarily in the same direction with high and low doses of amphetamine, or amphetamine and apomorphine administered a week apart from each other. Dopaminergic-cholinergic interactions were evident, since pilocarpine antagonized amphetamine-induced rotation whereas scopolamine did not; scopolamine elicited rotation in the same direction as that induced by amphetamine. Left and right striatal dopamine and tel-diencephalic norepinephrine levels were determined in rats injected with various doses of amphetamine and tested for rotation. There were significant bilateral differences in striatal dopamine which were related to the direction of rotation. Since amphetamine was found to be equally distributed to the two sides of the brain, the difference in striatal dopamine appeared to be the neurochemical substrate for rotation in normal rats. These results suggest that normal rats have asymmetrical levels of striatal dopamine as well as an asymmetrical complement of striatal dopamine receptors.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427609
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Comparative ultrastructure and blood-brain barrier in diapause and nondiapause larvae of the European corn borer Ostrinia nubilalis (Hübner) (1975)
    Springer
    Cell & tissue research 162 (1975), S. 499-510 
    Details
    ISSN: 1432-0878
    Keywords: Blood-brain barrier ; Moth ; Diapause ; ATPase ; Peroxidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Ultrastructural examination of diapause and nondiapause larval brains of the European corn borer disclosed anatomical differences that may be related to the insect's “blood-brain barrier.” The perineurial type I cells are quite closely appressed in the diapause brain, but thrown into extensive folds with large intercellular spaces in the nondiapause brain. The perineurial type II cells of diapause and nondiapause larvae are basically similar in general ultrastructure, and most likely form the basis for the “blood-brain barrier.” Horseradish peroxidase penetration studies indicated that the outer margin of the perineurial type II cells constitute the limits of infiltration into the brain. An enzymatic component of the “blood-brain barrier” is postulated in this insect. The localization of ATPase in the perineurial type II cells indicates that energy-requiring regulatory mechanisms may be localized here. Metabolic studies with isolated insect brains, coupled with recent evidence from mammalian systems, suggest that glial cells may be of importance in an enzymatic “blood-brain barrier.”
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00209349
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    In vivo sterol biosynthesis by pea aphid symbiotes as determined by digitonin and electron microscopic autoradiography (1977)
    Springer
    Cell & tissue research 176 (1977), S. 179-190 
    Details
    ISSN: 1432-0878
    Keywords: Cholesterol ; Symbiotes ; Aphids ; Digitonin ; Autoradiography
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Pea aphid primary symbiotes have previously been shown to synthesize cholesterol in vitro. Two electron microscopic techniques were used here to determine whether the symbiotes also synthesize cholesterol in vivo and whether this cholesterol is made available to the aphid. We also inquired into a possible role of secondary symbiotes in cholesterol biosynthesis. Treatment of aphids with digitonin resulted in significant alteration of ultrastructural sites in primary and secondary symbiote membranes. We concluded that these sites are areas of high cholesterol concentration in the symbiotes. Electron microscopic autoradiography with 3H-mevalonate precursor indicated that both primary and secondary symbiotes synthesize cholesterol; in both cases, the majority of grains were associated with the symbiote membranes. While the frequency of grains on the symbiotes remained constant, irrespective of incubation time in labelled media, the frequency of grains over surrounding tissues increased exponentially as the time of incubation was increased from 30 min to 8 h, indicating that symbiote cholesterol is transported to other tissues. High voltage electron microscopic autoradiography permitted thick section autoradiography, reducing the time of emulsion exposure from 54 days (thin section) to 12 days (0.5 μm sections).
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00229461
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    Paper (German National Licenses)
    Fulltext
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