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  • 1
    Electronic Resource
    Electronic Resource
    Supratentorial recurrences of gliomas. Morphological studies in relation to time intervals with astrocytomas (1977)
    Springer
    Acta neurochirurgica 37 (1977), S. 75-91 
    Details
    ISSN: 0942-0940
    Keywords: Supratentorial astrocytomas ; Recurrences of astrocytomas ; Classification of gliomas ; Recurrence intervals ; Radiotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary We report 137 recurrent supratentorial astrocytomas. The primary tumours diagnosed on the basis of a grading system with three stages were 72 astrocytomas I and 65 astrocytomas II. In the first group 14% of the recurrences were not changed, 55.5% became astrocytomas II, and 30.5% became glioblastomas. In the second group 55.4% were unchanged, and 44.6% became glioblastomas. The postoperative intervals until reintervention or death were statistically examined. It seems that the recurrence time chiefly depends on the nature of the primary tumour. The transformation of an astrocytoma I to a glioblastoma takes longer than the transformation of an astrocytoma II into a glioblastoma. In about two thirds of all astrocytomas an increase of malignancy is to be expected. From the histological picture it is not possible in an individual case to predict the likelihood or speed of malignant change. With regard to the effect of irradiation the authors conclude that radiotherapy most probably does not produce malignancy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01401927
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Supratentorial recurrences of gliomas. Morphological studies in relation to time intervals with oligodendrogliomas (1977)
    Springer
    Acta neurochirurgica 39 (1977), S. 15-25 
    Details
    ISSN: 0942-0940
    Keywords: Supratentorial oligodendrogliomas ; Recurrences of oligodendrogliomas ; Classification of gliomas ; Recurrence intervals ; Radiotherapy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary On the basis of a three stage grading system we report 23 stage one recurrent oligodendrogliomas (O 1), and 29 stage two recurrent oligodendrogliomas (O 2). In the O 1 group after the first interval 15 became O 2 and 2 became glioblastomas. Twenty tumours of the O 2 group after the first interval were not changed, three became oligodendroglioma-astrocytomas stage 2, and six became glioblastomas. The time relation for the recurrent phase in the primary O 1 group is calculated as 42 months, and in the primary O 2 group as 22 months, but this is without significance. For the development of malignancy, especially for the change to glioblastoma, a prominent participation by transformed local astrocytes seems to be essential. Postoperative irradiation most probably does not favour malignant change. A prolongation of the expectation of life by radiotherapy is not noticed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01405237
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Vergleichende hämodynamische Untersuchungen über die extrarenale Wirkung von Furosemid und Ethacrynsäure (1975)
    Springer
    Journal of molecular medicine 53 (1975), S. 1133-1134 
    Details
    ISSN: 1432-1440
    Keywords: Furosemide ; ethacrynic acid ; haemodynamic ; Furosemid ; Ethacrynsäure ; Hämodynamik
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Bei 12 Patienten (1–4 Monate nach akutem Myocardinfarkt) wurde das Verhalten hämodynamischer Parameter in Ruhe und unter Belastungsbedingungen vor und nach i.v. Injektion von Furosemid und Ethacrynsäure untersucht. Herzzeitvolumen, Herzfrequenz und arterieller Druck zeigen nach Applikation von Furosemid und Ethacrynsäure keine signifikanten Veränderungen. Während nach Injektion von Ethacrynsäure (trotz gleich starker Diurese wie nach Furosemid) eine gerichtete Veränderung des diastolischen Pulmonalarteriendruckes (PA d) und rechten Vorhofdruckes (RA) nicht zu beobachten ist, bewirkt Furosemid bereits wenige Minuten nach Applikation eine signifikante Senkung des linksventriculären Füllungsdruckes (PA d) und des rechten Vorhofdrucks (RA). Diese hämodynamischen Veränderungen sind als Folge eines direkten dilatorischen Effektes von Furosemid auf die Kapazitätsgefäße aufzufassen. Eine entsprechende direkte Gefäßwirkung von Ethacrynsäure ist nicht nachzuweisen.
    Notes: Summary The haemodynamic effects of intravenous injections of furosemide and ethacrynic acid were studied in 12 patients during rest and excercise. Cardiac output, heart rate and arterial blood pressure showed no significant changes after injection of furosemide or ethacrynic acid. Few minutes after injection of furosemide there were significant falls of pulmonary artery diastolic pressure and right atrial pressure, whereas no changes were seen after injection of ethacrynic acid. This initial effect of furosemide apparently is of primarily vascular origin, causing an increased peripheral venous capacitance. Ethacrynic acid failed to exhibit any direct vascular effect
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01614283
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    Paper (German National Licenses)
    Fulltext
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