ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
The determination of thermodynamic acidity constants (dissociation constants) requires the elimination of all salt effects by an extrapolation to zero ionic strength. Laborious curvefitting may be necessary, and the results may be of low accuracy unless an extensive series of data is available. It is shown that the extrapolation can be reduced to a simple extension of a straight line of small slope when suitable experimental data are combined in the proper way. Measurements of spectral absorption and of e.m.f., taken together, will yield thermodynamic acidity constants not obtainable by either method alone. The procedures are illustrated by the determination of the acidity constants for three uncharged acids (p-nitrophenol, 2,4-dinitrophenol and 4-chloro-2,6-dinitrophenol) and for three cationic acids (m-nitroanilinium-ion, p-chloranilinium-ion, and N,N-diethyl-p-toluidinium-ion).
Additional Material:
4 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19540370415
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