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  • 1
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Inorganic chemistry 14 (1975), S. 473-477 
    ISSN: 1520-510X
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 2
    Electronic Resource
    Electronic Resource
    s.l. : American Chemical Society
    Journal of the American Chemical Society 99 (1977), S. 5187-5189 
    ISSN: 1520-5126
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
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  • 3
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    Unknown
    Provincetown, Mass., etc. : Periodicals Archive Online (PAO)
    The Journal of Genetic Psychology. 130:1 (1977:Mar.) 155 
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  • 4
    Electronic Resource
    Electronic Resource
    Oxford, UK : Blackwell Publishing Ltd
    Physiologia plantarum 45 (1979), S. 0 
    ISSN: 1399-3054
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Biology
    Notes: Free and total putrescine and, to a lesser extent, spemidine accumulate in both roots and shoots of peas in response to potas stum deficiency and ammomnium supply. Free putrescine responds more sensitively than total putreseine to variatioin of nutrients. Accumulation of putrescine is more pronounced in the roots than in the shoots.
    Type of Medium: Electronic Resource
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  • 5
    Electronic Resource
    Electronic Resource
    Springer
    Pflügers Archiv 365 (1976), S. 81-87 
    ISSN: 1432-2013
    Keywords: Renal failure ; Micropuncture ; Diuretics ; Glomerular filtration rate ; Effective filtration pressure ; Renal blood flow
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The renal effects of furosemide in acute renal failure of the rat were studied using clearance and micropuncture techniques. Acute renal failure was induced by an intramuscular injection of 50% glycerol (10 ml/kg). Functional impairement of the glycerol treated animals consisted of a decrease in urinary sodium excretion, renal blood flow, total kidney GFR and effective filtration pressure of superficial nephrons. Effective filtration pressure was calculated from proximal free flow and stop flow pressure measurements. In contrast to control animals furosemide did not increase urine volume during acute renal failure due to a marked fall in GFR. Renal blood flow, as measured by an electromagnetic flowmeter, also decreased after furosemide in glycerol treated rats and increased in control animals. Furosemide reduced effective filtration pressure during acute renal failure to almost zero, whereas in control animals effective filtration pressure virtually remained constant.
    Type of Medium: Electronic Resource
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  • 6
    ISSN: 1432-2307
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In an autopsy material of 29 cases of the hypoplastic left heart syndrome coronary fibroelastosis was found in 1 case, endocardial fibroelastosis in 8 eases. Figures for 10 cases of the hypoplastic right heart syndrome were 6 cases of coronary fibroelastosis and 1 ease of endocardial fibroelastosis. Age ranged from stillborn up to 11 1/2 months. Coronary and endocardial fibroelastosis seemed to be mutually exclusive localizations of congenital fibroelastosis since in our material they did not occur together in the same hearts. In hypoplastic right hearts coronary fibroelastosis was either restricted to the right coronary artery (right circumflex and posterior interventricular branch), or it was found also in the left coronary artery (anterior interventricular branch), with the most serve affections always being situated in the right one. In the only case of coronary fibroelastosis among the hypoplastic left hearts the condition was limited to the anterior interventricular branch of the left coronary artery which communicated with the hypoplastic left ventricle by a fistula. Coronary fibroelastosis was exclusively found in branches supplying the hypoplastic right ventricle and/or in a branch connected by a fistula to the hypoplastic left or right ventricle. Endocardial fibroelastosis was generally found in hypoplastic left ventricles with either no outflow or with severe outflow obstruction. A theory concerning the aetiology of both coronary and endocardial fibroelastosis of the hypoplastic ventricles is proposed. It is argued that development of fibroelastosis may in both localizations be caused or favoured by the coincidence of two factors: abnormal haemodynamic conditions and poor oxygenation of blood and tissues. Observations made in a reference material of 35 hypoplastic left and 24 hypoplastic right hearts were in accordance with this view
    Type of Medium: Electronic Resource
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  • 7
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 301 (1977), S. 139-143 
    ISSN: 1432-1912
    Keywords: Renal function ; Renal blood flow ; Glomerular filtration rate ; Urine volume ; Urinary sodium excretion
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of the competitive angiotensin II antagonist saralasin (1-sarcosine-8-alanine-5-isoleucine-angiotensin II) on renal function in healthy rats and in rats with myohemoglobinuric acute renal failure were studied. Acute renal failure was induced by an intramuscular injection of 50% glycerol (10 ml ·kg−1). Functional impairment of the glycerol treated animals consisted in a decrease of renal blood flow (electromagnetic flowmeter) and GFR and in an increase of urine volume and arterial blood pressure. In healthy rats saralasin (6 μg·kg−1·min−1 i.v.) had no renal effects by itself but antagonized the angiotensin II (200 ng·kg−1·min i.v.) induced fall of renal blood flow and GFR and the increase of arterial blood pressure. Given to glycerol treated animals saralasin did not induce any change of arterial blood pressure, renal blood flow, GFR or the urinary excretion of fluid and sodium.
    Type of Medium: Electronic Resource
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  • 8
    Electronic Resource
    Electronic Resource
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 304 (1978), S. 289-296 
    ISSN: 1432-1912
    Keywords: Diuretics ; Clearance technique ; Micropuncture ; Tubular function
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The effects of ozolinone (3-methyl-4-oxo-5-piperidino-thiazolidine-2-ylidene) on renal tubular and glomerular functions were studied in rats using clearance and micropuncture techniques. Ozolinone (50 mg·kg−1 i.v., 50 mg·kg−1·h−1i.v.) markedly increased urine volume, urinary sodium excreation and — to a minor extent — also urinary potassium excretion. Fractional tubular sodium reabsorption fell by 14%. Renal blood flow, as measured by an electromagnetic flowmeter, increased considerably during the administration of the drug. Despite the fact that ozolinone increased intratubular hydrostatic pressure, whole kidney as well as single nephron GFR—measured at different tubular sites — remained constant due to an increase in glomerular capillary pressure (stopped flow measurements, servo nulling technique). The diuretic decreased intrinsic reabsorptive capacity of the proximal tubular epithelium as measured with the shrinking drop technique of Gertz, but had no clearcut effects on proximal fractional reabsorption. Fractional reabsorption was evaluated not only from free flow endproximal tubular fluid to plasma inulin measurements but also from transit time and half time of reabsorption (shrinking drop technique). An impressive depression of fluid, sodium and potassium reabsorption occurred in the loops of Henle after ozolinone. No further inhibition of fluid and sodium reabsorption in the distal convoluted tubules could be detected after the drug using a free flow recollection technique. Concerning the tubular site of renal action there is a striking similarity between ozolinone and the strong acting diuretic furosemide, although the chemical structures of these drugs are quite different. Differences between the two drugs exist concerning the endproximal tubular chloride concentration, which was decreased by furosemide but was not affected by ozolinone. This points to different effects of the drugs on proximal tubular bicarbonate reabsorption.
    Type of Medium: Electronic Resource
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  • 9
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 57 (1979), S. 87-91 
    ISSN: 1432-1440
    Keywords: Pregnancy ; Heart Rhythm ; Phase Coordination ; Schwangerschaft ; Herzrhythmus ; Phasenkoordination
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung An Schwangeren im 8. und 9. Schwangerschaftsmonat wurden, größtenteils bei systematischen Längsschnittuntersuchungen während der Nachtruhe, synchrone Registrierungen des mütterlichen und foetalen Elektrokardiogramms vorgenommen. Durch Untersuchung der Häufigkeitsverteilung der mütterlichen R-Zacken-Beginne innerhalb der foetalen Herzperiode sowie der Häufigkeitsverteilung der foetalen R-Zacken innerhalb der mütterlichen Herzperiode konnte der Nachweis erbracht werden, daß bei etwa ganzzahligem Frequenzverhältnis von 2:1 eine Phasenkoordination beider Herzrhythmen stattfindet, die zu einer Bevorzugung bestimmter Phasenbeziehungen führt. Die gefundene Phasenbeziehung läßt die Vermutung zu, daß sich der foetale Herzrhythmus dem Ablauf der mütterlichen Pulswellen als dem führenden Zeitgeberrhythmus innerhalb eines schmalen Ziehbereiches einordnet.
    Notes: Summary In pregnant women during 8th and 9th month of pregnancy simultaneous registrations of the maternal and the fetal electrocardiograms were carried out, generally by systematic long-term studies during night rest. It could be proofed by examinations of the frequency distribution of the maternal R-peaks within the fetal cardiac cycle as well as of the frequency distribution of the fetal R-peaks within the maternal cardiac cycle that around a whole number frequency relationship of both of the heart rhythms a phase coordination between maternal and fetal heart actions occurs, leading to a preference of a defined phase relationship. According to the detected phase relationship it can be presumed, that the fetal rhythm is triggered by the guiding maternal pulse wave rhythm within a small range.
    Type of Medium: Electronic Resource
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  • 10
    Electronic Resource
    Electronic Resource
    Springer
    Journal of molecular medicine 54 (1976), S. 137-140 
    ISSN: 1432-1440
    Keywords: Chronic persistent and aggressive hepatitis ; Aggressive Emperipolesis ; Lymphocyte cytotoxicity ; Cellular immune reaction ; Piecemeal necrosis ; Chronische persistierende und aggressive Hepatitis ; Aggressive Emperipolese ; Lymphozyten-Cytotoxizität ; Zelluläre Immunreaktion ; Mottenfraßnekrose
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung In Biopsiepräparaten von chronischen Hepatitiden wurde die Penetration und Zerstörung von Hepatocyten durch Lymphocyten (aggressive emperipolese) beschrieben und quantitativ ermittelt. Bei den untersuchten 48 Fällen von chronisch-persistierender Hepatitis spielte die aggressive Emperipolese nur eine untergeordnete Rolle und fehlte in vielen Fällen gänzlich. Demgegenüber ist sie bei den 36 untersuchten Fällen von chronischaggressiver Hepatitis stets deutlich, mitunter sogar in erheblichem Ausmaß vorhanden. Die aggressive Emperipolese ist — neben den Mottenfraßnekrosen — ein morphologisches, im Leberstanzzylinder lichtmikroskopisch nachweisbares Substrat für den Prozeß der „self-perpetuation“ des chronisch-entzündlichen Geschehens und ein weiteres Kriterium für die Abgrenzung der beiden Haupttypen der chronischen Hepatitis.
    Notes: Summary The penetration and destruction of hepatocytes by lymphocytes (aggressive emperipolesis) has been described and examined quantitatively in biopsy specimens of chronic hepatitis. In 48 cases of chronic persistent hepatitis, the aggressive emperipolesis was rare and, obviously, not of great importance; sometimes there was no emperipolesis at all. In 36 cases of chronic aggressive hepatitis, however, emperipolesis was always evident, usually even to a very high extent. The aggressive emperipolesis — as well as the piecemeal necrosis — is a significant phenomenon which can be seen in the light microscope in liver biopsies and gives evidence to the fact that this chronic inflammatory process is a progressive one; furthermore, it is an additional criterion to differentiate the two main types of chronic hepatitis.
    Type of Medium: Electronic Resource
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