ISSN:
0021-9541
Keywords:
Life and Medical Sciences
;
Cell & Developmental Biology
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Biology
,
Medicine
Notes:
When substituted steroids of several classes are added to cultures of rat bone marrow cells in the presence of erythropoietin a consistent enhancement of the number of colonies of hemoglobin synthesizing cells is obtained. Maximum steroid effectiveness was found to be between 10-6 and 10-7 M. Representative compounds of several classes of steroids were examined for their ability to enhance colony growth, including δ 4-estrenes, δ 4-androstenes, 5α-H androstanes and estranes, 5β-H estranes, pregnanes and androstanes. While testosterone and its 5α-H derivatives had little or no activity, many synthetic derivatives of testosterone were highly active in increasing erythroid colony growth. All 5β-H androstanes, estranes, and all but one 5β-H pregnane were active. Cortisol consistently inhibited colony growth and estradiol and progesterone had no significant effect.
Additional Material:
2 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/jcp.1040880202
Permalink