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  • 1
    Electronic Resource
    Electronic Resource
    Early mitochondrial damage in the induction of haemorrhagic necrosis in the Crocker sarcoma (S 180) by endotoxin (1979)
    Springer
    Journal of cancer research and clinical oncology 93 (1979), S. 245-254 
    Details
    ISSN: 1432-1335
    Keywords: Mitochondrial damage ; Haemorrhagic necrosis ; Endotoxin
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Disturbances in the functional properties of tumor mitochondria have been studied during the course of induction of haemorrhage brought about by endotoxin in the murine Crocker sarcoma (S 180). Extensive impairment of function was already present in mitochondria isolated from control tumors, as shown by low respiratory control ratios. The existing mitochondrial damage intensified promptly in response to injection of endotoxin long before the onset of haemorrhage at 4 h. The nature of the additional damage took two forms, depending on the duration of exposure to endotoxin; first, at 30 min, a true uncoupling of oxidative phosphorylation was seen, largely reversible in vitro by pre-treatment of the isolated organelles with bovine serum albumin (BSA). Second, at 1 h and later, oxygen utilisation in the presence of succinate, ADP and inorganic phosphate (P i) was depressed. The pre-addition of BSA consistently lowered respiration rates with succinate andP i in all preparations. The extent of endogenous inhibition of the adenine nucleotide translocase appeared unaltered by endotoxin in vivo.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00964580
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  • 2
    Electronic Resource
    Electronic Resource
    Water-soluble photocurable elastomer (1979)
    New York, NY [u.a.] : Wiley-Blackwell
    Journal of Applied Polymer Science 23 (1979), S. 115-122 
    Details
    ISSN: 0021-8995
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: A low molecular weight copolymer of vinylbenzyl chloride and butadiene was quaternized with N-dimethylaminoethylmethacrylamide. The resin was coated from water solution to give a photorelief plate which could be developed with water. A photocured protective coating on steel showed good toughness.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/app.1979.070230110
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Identification of a nitrone as an in vitro metabolite of N-methylamphetamineAbbreviation: NMA = N-methylamphetamine. (1978)
    Chichester : Wiley-Blackwell
    Biological Mass Spectrometry 5 (1978), S. 418-422 
    Details
    ISSN: 0306-042X
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Notes: The relatively labile nitrone, α-methyl-(N-methylene)benzeneethanamine N-oxide was isolated from incubates of (±)-N-methylamphetamine with fortified liver homogenates from rats and rabbit. Identification of the nitrone was confirmed directly by gas chromatography and gas chromatography mass spectrometry and, after its conversion to isoxazolidine adducts by the action of methyl and ethyl acrylate. An authentic sample of the nitrone was synthesized unequivocally from N-hydroxyamphetamine and formaldehyde. The isomeric nitrone, N-(α-methylbenzeneethylidene)methylamine N-oxide, was also synthesized and its gas chromatographic and gas chromatographic mass spectrometric characteristics determined to confirm that the metabolically formed nitrone was not N-(α-methylbenzeneethylidene)methylamine N-oxide. Two previously unreported metabolites of (±)-N-methylamphetamine, N-hydroxyamphetamine and 1-hydroxy-1-phenyl-2-propanone, were isolated from rat in vitro experiments; the latter metabolite was not produced in vitro by rabbit liver homogenates.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bms.1200050609
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    Paper (German National Licenses)
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