ISSN:
1432-2072
Keywords:
Amphetamine
;
Memory storage processes
;
Avoidance training
;
Retrograde memory enhancement
;
Retrograde amnesia
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract These experiments examined the effects of d-amphetamine on retention of one-trial inhibitory (passive) avoidance training in mice. Water-deprived mice were pretrained to lick from a water spout at the end of a darkened compartment. Footschock was administered during licking after 4, 6, or 7 days of pretraining. Retention performance (latency to lick) was measured 24 h after training. The effects on memory of posttraining amphetamine varied not only with amphetamine dose but also with the amount of pretraining. In animals pretraining for 7 days, 0.3 and 1.0 mg/kg but not 0.03, 0.1, or 3.0 mg/kg posttraining amphetamine significantly enhanced later retention performance. In mice pretrained for 6 days, 1 mg/kg amphetamine also enhanced retention performance. However, in mice pretrained for only 4 days, 1 mg/kg amphetamine impaired later retention performance. These results are consistent with the view that posttraining treatments may affect memory storage processes by interacting with training-related arousal levels.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00426535
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