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  • 1
    Electronic Resource
    Electronic Resource
    Negative ion effects in CO2 convection laser discharges (1978)
    Springer
    Applied physics 16 (1978), S. 111-118 
    Details
    ISSN: 1432-0630
    Keywords: 42.55D
    Source: Springer Online Journal Archives 1860-2000
    Topics: Mechanical Engineering, Materials Science, Production Engineering, Mining and Metallurgy, Traffic Engineering, Precision Mechanics , Physics
    Notes: Abstract Negative ions are computed to be formed on a time scale and in quantities such that they may be a cause of plasma instability observed in low pressure electrical discharge convection CO2 lasers. In a typical CO2−N2−He−H2O laser mixture the principal ions are CO 3 − , CO 4 − and H− with the total negative ion densityn − given by 0.1n e 〈n −〈n e , wheren e is the electron density: but if the gases are re-cycled or if there is an air leak NO 2 − and NO 3 − are formed in significant amounts andn − can become greater thann e in a time considerably less than the gas dwell time in the electrical excitation discharge. CO is effective in reducingn − in a system without re-cycling, but is ineffective in a re-cycled system with the oxides of nitrogen present.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00931431
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Dissociation of biochemical and hypotensive effects of debrisoquine in hypertensive patients (1979)
    Springer
    European journal of clinical pharmacology 16 (1979), S. 81-86 
    Details
    ISSN: 1432-1041
    Keywords: debrisoquine ; hypertension ; renin ; catecholamines ; platelet monoamine oxidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The 24 h urinary excretion of adrenaline, noradrenaline, metadrenaline, normetadrenaline and vanillylmandelic acid, plasma renin activity and plasma and urinary debrisoquine were measured before and during chronic treatment with oral debrisoquine in 14 in-patients with essential hypertension. There was a significant fall (mean ±SD) in the 24 h urinary excretion of vanillylmandelic acid (15.3±2.8 to 6.7±1.9 µmol) noradrenaline (199.0±105.8 to 125.2±43.3 nmol) and plasma renin activity (0.71±0.47 to 0.40±0.20 pmol Angio I ml−1 h−1) while the urinary normetadrenaline/noradrenaline ratio increased (10.4±6.1 to 17.1±5.1). No significant change was seen in the output of adrenaline or of O-methylated metabolites. Debrisoquine produces extensive noncompetitive inhibition of platelet monoamine oxidase in vivo at low therapeutic plasma concentrations. These changes support the view that treatment with debrisoquine produces intraneuronal inhibition of monoamine oxidase and post-ganglionic blockage. There was a significant correlation between the change in standing diastolic blood pressure and the daily dose (rs=−0.52), pre-dose plasma concentration (rs=−0.85) and mean daily urinary recovery (rs=−0.80), of debrisoquine. The full extent of the biochemical changes were seen at low dose and low plasma concentration and were not directly correlated with the fall in standing or supine blood pressure.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00563111
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Acebutolol in hypertension: Relationships between drug concentration and effects (1978)
    Springer
    European journal of clinical pharmacology 14 (1978), S. 383-390 
    Details
    ISSN: 1432-1041
    Keywords: Acebutolol ; N-acetyl metabolite ; drug plasma concentrations ; plasma renin activity ; hypertension ; β-blockade
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary Relationships between plasma concentrations of acebutolol (Ac) and its N-acetyl metabolite (Am) and pharmacological effects were studied in patients with essential hypertension. In an acute study (N=7) 400 mg oral acebutolol produced similar peak plasma levels of Ac and Am but Am had a longer half life. Group mean pulse and blood pressure fell significantly, although the size of individual blood pressure fall varied five-fold. There was no significant change in plasma renin activity. Correlations were found between drug concentration and β-blockade, assessed as % reduction in exercise tachycardia, and between both of these and the fall in post exercise systolic blood pressure. Similar comparisons were made in a chronic optimum dose study (N=11) both pre-dose and three hours post-dose. Am concentration was consistently higher than Ac at both times. Blood pressure was lowered equally pre-and post-dose when compared to placebo and plasma renin activity (PRA) was reduced on active treatment. Correlations were again shown between drug concentrations and β-blockade but none were found with changes in blood pressure or PRA. Between subject differences in blood pressure response could not be fully explained in terms of the other measurements but it is unlikely that pharmacokinetic differences are the major source of this variability.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00716378
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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