ISSN:
1432-1076
Keywords:
Osteogenesis imperfecta
;
Collagen types
;
Bone
;
In vitro study
;
Immunofluorescence
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Samples of bone from a patient with osteogenesis imperfecta were found to synthesize and contain type III collagen as well as type I collagen. Normal bone contains only type I collagen except in the lining cells of the bone marrow cavities. In the patient's tissue, type III collagen was localized in nonfibrillar structures in discrete areas of the bone. These and previous studies indicate that certain types of osteogenesis imperfecta may be caused by a failure of normal bone maturation and the sites in which the type III collagen is found appear to be defects in the bone.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00470603
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