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  • 1975-1979  (2)
  • 6 beta-hydroxycortisol  (1)
  • Solanum × chaucha  (1)
  • Cytoprotektion
  • 1
    Electronic Resource
    Electronic Resource
    Springer
    European journal of clinical pharmacology 15 (1979), S. 193-197 
    ISSN: 1432-1041
    Keywords: norethisterone ; rifampicin ; enzyme induction ; antipyrine ; 6 beta-hydroxycortisol ; gamma-glutamyltranspeptidase
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The pharmacokinetics of norethisterone have been studied in 8 women during and one month after treatment with rifampicin (450–600 mg/day). Rifampicin caused a significant reduction in the A. U. C. of a single dose of 1 mg norethisterone from 37.8±13.1 to 21.9±5.9 ng/ml X h (p〈0.01). The plasma norethisterone half life (β-phase) was also reduced from 6.2±1.7 to 3.2±1.0 h (p〈0.0025). In one additional woman on long term oral contraceptive therapy the 12 hour plasma norethisterone concentration was reduced by rifampicin from 12.3 ng/ml to 2.3 ng/ml. Rifampicin caused a significant increase in antipyrine clearance, 6β-hydroxycortisol excretion and plasma gamma-glutamyltranspeptidase activity but there were no significant correlations between changes in these indices of liver microsomal enzyme induction. There was a significant correlation between the percentage increase in antipyrine clearance and the percentage decrease in norethisterone A. U. C. during rifampicin. The changes in norethisterone pharmacokinetics during rifampicin therapy are compatible with the known enzyme inducing effect of rifampicin.
    Type of Medium: Electronic Resource
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  • 2
    ISSN: 1573-5060
    Keywords: Solanum × chaucha ; potato ; triploid ; taxonomy ; variation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Agriculture, Forestry, Horticulture, Fishery, Domestic Science, Nutrition
    Notes: Summary The variation in Solanum × chaucha Juz. et Buk. (2n=3x=36) was studied using 114 accessions from the Potato Collection maintained by the International Potato Center. These accession represented less than 5% of the collection originally screened for ploidy. Twenty morphological characters of the tubers, inflorescences and leaves were scored. The accessions were grouped into 20 morphotypes on the basis of the tuber characters. Two-qualitative characters, red-anther tip and sky-blue flowers were diagnostic of 4 morphotypes, but the variation of the quantitative characters overlapped among morphotypes, and were of limited value. Electrophoretic separation of tuber proteins in 7.5% polyacrylamide gels generally confirmed the morphotype groupings. It is concluded that each of the morphotypes represents a single genotype, and these are named according to the International Code of Nomenclature for Cultivated Plants. The variation within S. × chaucha apparently has been restricted by its hybrid origin.
    Type of Medium: Electronic Resource
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