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  • 1975-1979  (2)
  • Adrenal catecholamines  (1)
  • Cyclopropane  (1)
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  • 1975-1979  (2)
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    The effect of two diverse inhalation anesthetic agents on serotonin in discrete regions of the rat brain (1975)
    Springer
    Experimental brain research 24 (1975), S. 203-207 
    Details
    ISSN: 1432-1106
    Keywords: General anesthesia ; Neurohormones ; Serotonin ; Halothane ; Cyclopropane
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Sensitive radioisotopic enzymatic methods were used to determine 5-HT levels in 16 different regions of brain from rats anesthetized for 90–105 min with 1% halothane or 18% cyclopropane. These two anesthetics were chosen because of their differing effects on the electroencephalogram and on the cardio-vascular and respiratory systems. 5-HT levels in the nucleus amygdaloideus centralis, substantia nigra, and nucleus centralis superior were increased after administration of either anesthetic, but only anesthesia with cyclopropane was associated with an increase in 5-HT level in the nucleus raphe dorsalis. The changes in levels of transmitter does not distinguish cause from effect of anesthesia, and further experiments are needed to delineate what role, if any, the specific areas play in muscle relaxation, analgesia, sleep or anesthesia.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00234063
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Alterations of mouse adrenal medullary catecholamines and enzymes in response to attack: Effect of pre- and post-treatment with phenobarbital (1976)
    Springer
    Psychopharmacology 51 (1976), S. 53-57 
    Details
    ISSN: 1432-2072
    Keywords: Attack stress ; Aggressor mice ; Victim mice ; Adrenal medullary enzymes ; Adrenal catecholamines ; Phenobarbital
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Group-housed male C57BR/cdJ mice (victims) were exposed to attack for 10 min daily for up to 14 days by male Swiss-Webster mice, made aggressive by prolonged isolation. Their adrenal glands were analyzed for tyrosine hydroxylase (TH) and phenylethanolamine-N-methyltransferase (PNMT) activities and for norepinephrine (NE) and epinephrine (EPI) concentrations. TH was increased to 41% above control after two exposures and remained elevated through 14 exposures to attack. PNMT was increased to 29% above control after 2 days and increased further to 50% above control after 14 days of attack. Both NE and EPI increased to 88% and 51% above control, respectively, after 7 days. In victim mice recuperating after 1 week of daily stress, EPI levels and PNMT activities were back to normal after 4 days whereas NE levels and TH activities returned to normal only after 1 week. Phenobarbital (40 mg/kg, i.m.) was effective in preventing the biochemical changes when given 2 h prior to each daily attack but was ineffective when given immediately after each daily stress.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426321
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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