ISSN:
1432-2072
Keywords:
Prolactin
;
LSD
;
Dopamine
;
Serotonin
;
Methysergide
;
Chlorpromazine
;
Quipazine
;
Alpha-methylparatyrosine
;
Apomorphine
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Lysergic acid diethylamide (LSD), 0.05 mg/kg and 0.20 mg/kg, significantly decreased plasma prolactin (PRL) levels in male rats. LSD, 0.20 mg/kg, also inhibits the increase in plasma PRL levels produced by chlorpromazine (CPZ), 5 mg/kg, and alpha-methylparatyrosine (AMPT), 50 mg/kg, both of which interfere with dopaminergic inhibition of PRL secretion. LSD was more potent than methysergide, a serotonin receptor blocker, in lowering plasma PRL levels and more potent than apomorphine, a known direct acting dopamine agonist, in blocking the increase in plasma PRL produced by quipazine, a 5-HT agonist. These results suggest LSD has potent dopamine agonist properties on the rat pituitary or hypothalamic dopamine receptors which directly or indirectly inhibit PRL secretion.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00426539
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