ISSN:
1432-2072
Keywords:
Precursor amino acids
;
Diet supplements
;
Aggressive behavior
;
Motor activity
;
Norepinephrine
;
Dopamine
;
Serotonin
;
Tolerance
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Abstract Male albino mice were maintained on a semisynthetic 12% casein protein diet for 2 weeks, then switched to diets modified by the addition of a 4% L-amino acid supplement (L-tyrosine, L-phenylalanine, and L-tryptophan) or 4% casein (control). Territorial-induced aggressive behavior increased following 1 week on the amino acid supplements, especially after tyrosine, but an apparent tolerance developed to these effects after 5 weeks on the amino acid supplements. Locomotor activity also increased following 1 week on the supplements, most notably after phenylalanine alone or in combination with tyrosine, and these effects tended to persist after 5 weeks on the supplements. Endogenous whole brain levels of dopamine, norepinephrine, serotonin, 5-hydroxyindoleacetic acid, tyrosine, phenylalanine, and tryptophan showed no tolerance to increased concentrations of brain catecholamines and indoleamines over the 5-week period, and no clear relation between the concentrations of these monoamines and the behavioral changes.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00428324
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