ISSN:
0306-042X
Keywords:
Chemistry
;
Analytical Chemistry and Spectroscopy
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
A highly sensitive and specific method for the determination of nifedipine in plasma is described. Nifedipine was oxidized to its pyridine analogue with nitrous acid and determined by selected ion monitoring. Deuterium labeled nifedipine was used as an internal standard. Plasma levels as low as 5 ng ml-1 were measured. The usefulness of the method was demonstrated by obtaining plasma concentration curves for humans after an oral dose of 10 mg.
Additional Material:
5 Ill.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/bms.1200050310
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