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  • 1975-1979  (4)
  • Biliary Excretion  (2)
  • Analytical Chemistry and Spectroscopy  (1)
  • Polymer and Materials Science
  • 1
    Electronic Resource
    Electronic Resource
    Effect of nafenopin (SU-13, 437) on liver function (1975)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 290 (1975), S. 235-250 
    Details
    ISSN: 1432-1912
    Keywords: Nafenopin ; Biliary Excretion ; Hepatic Uptake ; Hypolipidemic Agents ; Dibromosulphthalein
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Rats treated with the hypolipidemic agent, nafenopin (SU-13, 437) exhibit a higher plasma retention and a markedly reduced biliary excretion of organic anions, such as sulfobromophthalein (BSP) and its dibromo analog (DBSP), indocyaninegreen (ICG), succinylsulfathiazole (SST) and polar metabolites of bilirubin and the carcinogens 7, 12-dimethylbenzanthracene (DMBA) and 3,4-benz-pyrene (BP), despite an increase in liver mass and a profound choleresis. However, taurocholate is not affected in this manner, which supports the idea of a transport mechanism for taurocholate that differs from that of other organic anions. A pharmacokinetic study was made for DBSP in vivo. After nafenopin treatment, primary hepatic uptake (k12) and transport from liver into bile (k23) are reduced in vivo. Infusion studies indicate that biliary transport maximum (Tm) for DBSP is also decreased although the calculated hepatic storage (S) is only moderately affected. In the isolated perfused liver, hepatic clearance and biliary excretion of BSP are reduced by two-thirds. The time course of anion tranport inhibition and the hepato-biliary disposition of 14C-nafenopin suggest a direct effect of the drug. The extra liver mass induced by nafenopin appears to be hypo- or nonfunctional with respect to hepatic transport of organic anions.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00510553
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Effect of nafenopin (SU-13,437) on liver function (1975)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 290 (1975), S. 221-234 
    Details
    ISSN: 1432-1912
    Keywords: Biliary Excretion ; Choleresis ; Nafenopin Enterohepatic Circulation ; Pharmacokinetics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Administration of nafenopin (SU-13-437) to male rats for two days leads to a doubling of bile production and a 50% increase in liver weight. These two effects have been shown not to be directly interrelated. A marked decrease in biliary bile salt concentration suggests that the bile salt independent flow is stimulated. The extra bile produced is probably of canalicular origin since bile to plasma concentration ratios of erythritol are unchanged. At least three polar metabolites of nafenopin have been observed in rat bile. Obervations in rats with partial biliary fistulas indicate that the drug and its metabolites undergo extensive enterohepatic circulation. Our studies support the view that much of the enhanced bile flow is associated with the presence of nafenopin and/or its metabolites within the hepatobiliary system. However, the response is too extensive to be explained merely by osmotic choleresis. Induced structural changes in the liver may also account for some of this effect.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00510552
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    A therotical basis for the “solvent effect” (1978)
    Weinheim : Wiley-Blackwell
    Journal of High Resolution Chromatography 1 (1978), S. 275-276 
    Details
    ISSN: 0935-6304
    Keywords: Gas Chromatography ; Capillary ; Splitless injection ; Theoretical basis for reconcetration by solvent effects ; Guidelines for an effective solvent effect, in literature citation ; Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Additional Material: 1 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/jhrc.1240010513
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Gewässerschutz in der BASF AG, Ludwigshafen (1978)
    Weinheim : Wiley-Blackwell
    Chemie Ingenieur Technik - CIT 50 (1978), S. 510-518 
    Details
    ISSN: 0009-286X
    Keywords: Chemistry ; Polymer and Materials Science
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Waste water purification at BASF, Ludwigshafen/Rh. The manifold problems encountered in the field of waste water treatment in the chemical industry are considered, together with the tasks involved, possible solutions, and costs incurred, for the example of BASF AG in Ludwigshafen. This example is particularly interesting because it shows how the waste water problems of a chemical factory that has been in existence for over a centurvey could be solved in the course of a ten-year plan. Twenty years after the inception of this plan, costs and success can now be quantified.
    Additional Material: 13 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/cite.330500705
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    Paper (German National Licenses)
    Fulltext
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