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  • 1975-1979  (6)
  • Chemical Engineering  (3)
  • Dopamine receptors  (3)
  • Bacillus thuringiensis
  • Ultrasound technique
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Material
Years
Year
Keywords
  • 1
    Electronic Resource
    Electronic Resource
    A gradual score to evaluate the climbing behaviour elicited by apomorphine in mice (1978)
    Springer
    Psychopharmacology 56 (1978), S. 233-234 
    Details
    ISSN: 1432-2072
    Keywords: Stereotyped behaviour ; Apomorphine ; Dopamine receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Mice treated with apomorphine tend to adopt a vertical position in a stereotyped manner. A quantal evaluation of this behaviour, taking into account its frequency and duration, leads to a biphasic dose-response curve that reveals opposite actions of the dopamine agonist.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431856
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    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Climbing behavior induced by apomorphine in mice: a simple test for the study of dopamine receptors in striatum (1976)
    Springer
    Psychopharmacology 50 (1976), S. 1-6 
    Details
    ISSN: 1432-2072
    Keywords: Climbing behavior ; Dopamine receptors ; Apomorphine ; Antipsychotics
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Mice treated with low doses of apomorphine tend to adopt a vertical position along the walls of their cage. Optimal conditions have been defined to obtain a reliable dose-response relationship. This peculiar behavior appears to be elicited by stimulation of dopamine receptors in the striatum: it is suppressed after coagulation of this structure while it is facilitated when these receptors are made hypersensitive by previous treatments with 6-hydroxydopamine or haloperidol; on the other hand, it is not modified by coagulation of the nucleus accumbens. The relative efficacy of various agonists and antagonists of dopamine receptors have been determined on this test. It appears that this stereotyped behavior might represent a convenient mean to assess the stimulation of striatal dopamine receptors in mice.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00634146
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    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    3H-Domperidone: A selective ligand for dopamine receptors (1979)
    Springer
    Naunyn-Schmiedeberg's archives of pharmacology 308 (1979), S. 231-237 
    Details
    ISSN: 1432-1912
    Keywords: 3H-Domperidone ; Dopamine receptors
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary 3H-Domperidone, a potent antagonist of dopamine but less lipophilic than neuroleptic drugs, was studied as a potential ligand for cerebral dopamine receptors. It labeled with high affinity an apparently homogeneous population of non-interacting sites in a particulate fraction of mouse striatum. Association occurred rapidly and dissociation was relatively slow (t1/2≃4min); this allowed extensive washing of membranes which reduced the non-specific binding to values as low as 5% of the total binding. Consistent Kd values of 0.7 nM were obtained by analysing by various methods either the kinetics of binding or the saturation of binding sites at equilibrium. The relative potencies of various dopamine receptor agonists or antagonists to inhibit 3H-domperidone binding, paralleled their pharmacological activity. On the other hand, a variety of non-dopaminergic agents failed to inhibit 3H-domperidone binding. The findings indicate that striatal dopamine receptors are selectively labeled by this 3H-ligand. In various non-striatal regions of mouse brain the saturable binding of 3H-domperidone was almost entirely inhibited by apomorphine indicating its selectivity for dopamine receptors in spite of the low density of the latter. This was not the case for the binding of 3H-spiperone, evaluated on the same preparations, indicating that 3H-domperidone probably represents the most selective ligand presently available.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00501387
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Analytical model reduction of large scale linear dynamic systems (1977)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 23 (1977), S. 948-951 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A class of dynamic model approximation techniques based on a frequency domain Taylor series expansion is presented. These methods yield low-order models and are analytical rather than computational in nature; that is, one can retain important parameters (which may be time varying) from the original model in functional form in the low-order model. This feature is very attractive for on-line updating of the simplified model and subsequent control of the process. An example for a tenth-order original model has shown that the analytical low-order models provide excellent approximations to the step response of the original system.
    Additional Material: 1 Tab.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690230627
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Liquid holdup and dispersion in trickle-bed reactors (1976)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 22 (1976), S. 953-956 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Additional Material: 6 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690220531
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    A new tracer method for determination of liquid-solid contacting efficiency in trickle-bed reactors (1976)
    Hoboken, NJ : Wiley-Blackwell
    AIChE Journal 22 (1976), S. 894-904 
    Details
    ISSN: 0001-1541
    Keywords: Chemistry ; Chemical Engineering
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: A new tracer technique is reported for the determination of liquid-solid contacting efficiency and liquid holdup in trickle beds packed with small alumina particles. Holdup was a function of liquid mass velocity for both porous and nonporous packing. Contacting efficiency remained uniform at a level of 65%.
    Additional Material: 10 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/aic.690220513
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    Paper (German National Licenses)
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