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  • 1975-1979  (5)
  • Biochemistry and Biotechnology  (2)
  • General Chemistry  (2)
  • Ultrastructure  (1)
  • Gene expression
  • 1
    Electronic Resource
    Electronic Resource
    Microbodies of the rat renal proximal tubule: Ultrastructural and cytochemical investigations (1975)
    Springer
    Cell & tissue research 157 (1975), S. 283-305 
    Details
    ISSN: 1432-0878
    Keywords: Microbodies ; Kidney ; Proximal tubule ; Ultrastructure ; Cytochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The present study was undertaken to provide a detailed morphological and cytochemical characterization of the microbodies of the rat renal proximal tubule following perfusion fixation. The following observations were made: 1) Two basic types of microbodies (Mb-I and Mb-II) can be identified. Mb-I have both circular and tubular profiles which are located peripherally within the granular matrix of these microbodies. Mb-II have marginal plates and crystalloid inclusion in addition to circular and tubular profiles. 2) Circular and tubular profiles, 100 nm in diameter, described by previous investigators as being infrequent in occurrence, are the most consistent morphological characteristic of rat renal microbodies after perfusion fixation. These profiles have a homogeneous center surrounded by a double or single ring of granules. The uniform size and spacing of these granules within profiles establish a basic 100 Å periodicity found in both types of microbodies. 3) Evidence is presented which suggests that both “nucleoids” and “tubular protrusion rods” as described by other investigators of the rat renal microbodies may result from poor fixation and/or osmotic stress. 4) The density of the matrix of Mb-I is, in contrast to previous reports, greater than the density of adjacent mitochondria. 5) Marginal plates or crystalloid inclusions were demonstrated in some microbodies (Mb-II) of all the rats studied; periodicities of 100, 200, and 300 Å were identified within these structures. 6) Both types of microbodies were positive for catalase activity, but were negative for acid phosphatase activity. On the basis of both morphological and cytochemical criteria, it seems plausible that these two populations of renal microbodies (Mb-I and Mb-II) represent a morphological and functional continuum.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00225521
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Efficient biokinetic experimental designs (1975)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 17 (1975), S. 557-570 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Of the experimental methods available for obtaining data to estimate the biological kinetic parameters μm, Ks, and Yeach requires considerable experimental effort, yet often yields somewhat imprecise estimates of the parameters, particularly Ks. Therefore it would be worthwhile to seek ways to get parameter estimates of greater precision using less experimental effort. The precision of parameter estimates is strongly dependent, upon the settings of the independent, variables used in the experiments. This dependence is explained and an attempt made to show how experimental settings can be determined that lead efficiently to precise parameter estimates with minimal effort.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260170408
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Using multiresponse data to estimate biokinetic parameters (1975)
    New York, NY [u.a.] : Wiley-Blackwell
    Biotechnology and Bioengineering 17 (1975), S. 571-583 
    Details
    ISSN: 0006-3592
    Keywords: Chemistry ; Biochemistry and Biotechnology
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Biology , Process Engineering, Biotechnology, Nutrition Technology
    Notes: Biokinetic parameters are usually calculated from slopes and intercepts taken from plots of experimental data. One response at an item is plotted and used for parameter estimation. Aside from problems that may be caused by transformations made when the data are plotted, this approach has the weakness of not using all the data simultaneously when there is more than one response. This paper shows how multiresponse biological data can be handled to get parameter estimates that are much more precise than those obtained using conventional methods.
    Additional Material: 9 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/bit.260170409
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Asymmetrische Synthese von 2-Alkylcyclohexanonen an festen TrägernDiese Arbeit wurde vom National Research Council of Canada und der York University unterstützt. (1979)
    Weinheim : Wiley-Blackwell
    Zeitschrift für die chemische Industrie 91 (1979), S. 255-255 
    Details
    ISSN: 0044-8249
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/ange.19790910327
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  • 5
    Electronic Resource
    Electronic Resource
    Asymmetric Synthesis of 2-Alkylcyclohexanones on Solid PhasesThis work was supported by the National Research Council of Canada and York University. (1979)
    Weinheim : Wiley-Blackwell
    Angewandte Chemie International Edition in English 18 (1979), S. 221-222 
    Details
    ISSN: 0570-0833
    Keywords: Chemistry ; General Chemistry
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/anie.197902211
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    Paper (German National Licenses)
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