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Hormonstatus bei Frauen nach Hysterektomie im Vergleich zu Kontrollen (1978)

Kaiser, R. ; Geiger, W. ; Künzig, H. -J.

Springer

Archives of gynecology and obstetrics 226 (1978), S. 363-368

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ISSN: 1432-0711

Keywords: Hysterectomy ; Ovarian function ; Premenopause ; Hormonal cycle ; Hysterektomie ; Ovarialfunktion ; Pramenopause ; Zyklus

Source: Springer Online Journal Archives 1860-2000

Topics: Medicine

Description / Table of Contents: Zusammenfassung Bei 48 Frauen nach Hysterektomie im Alter von 28–43 Jahren wurden 5–10 Jahre später Plasmabestimmungen von FSH, LH, Östradiol-17β und Progesteron durchgeführt. Zum Vergleich diente eine Gruppe prämenopausaler Frauen mit fluktuierender FSH-Erhöhung und eine weitere mit stabilem Hypergonadotropismus. Es wurde festgestellt, daß nach Hysterektomie bei den Frauen unter 40 Jahren stets, zwischen 41 und 45 Jahren in drei Viertel und mit mehr als 46 Jahren in der Hälfte eine normogonadotrope und normosteroidale Ovarialfunktion vorlag. Die Frauen mit fluktuierendem oder stabilem Hypergonadotropismus waren jedoch nach Hysterektomie durchschnittlich um 2 Jahre jünger als die prämenopausalen Frauen mit entsprechender Ovarialfunktion. Eine gewisse zeitliche Vorverlegung von nachweisbaren Kriterien einer definitiven Ovarialinsuffizienz war bei einem Teil der Frauen damit nicht auszuschließen.

Notes: Summary Plasma-FSH, -LH, -Estradiol-17β, and -Progesterone were determined weekly in women aged between 28 and 43 years who had been hysterectomized 5–10 years before. The endocrine parameters were compared with those of women with a normal cycle and two groups of premenopausal women, the one showing a fixed hypergonadotropic state, the other slightly elevated but still cyclic fluctuations of FSH and normal LH values. After hysterectomy, normal ovulatory cycles were found in all women of up to 40 years, in 75% of those between 41 and 45 years and in 50% of those beyond 46 years. The average age of women with fluctuating or fixed hypergonadotropism was 2 years less in the hysterectomiced group. Thus, a certain acceleration of ovarian insufficiency caused by hysterectomy cannot be denied.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF02119227

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Polarity change in capillary GC by serial-column temperature optimization (SECAT mode in capillary GC) (1979)

Kaiser, R. E. ; Rieder, R. I.

Weinheim : Wiley-Blackwell

Journal of High Resolution Chromatography 2 (1979), S. 416-422

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ISSN: 0935-6304

Keywords: Gas chromatography ; Capillary, glass ; SECAT-technique=stepless fine tuning of capillary selectivity by serial column temperature optimization ; Exponential influence of temperature on selectivity over a wide range found ; SECAT-technique ready for automation of column adjustment on sample composition polarity ; Instrumental and methodological details for primitive self made solution given ; Chemistry ; Analytical Chemistry and Spectroscopy

Source: Wiley InterScience Backfile Collection 1832-2000

Topics: Chemistry and Pharmacology

Notes: GC, including capillary GC, is rather inflexible, if a certain column length and stationary phase has been fixed for a given analytical problem. If the sample composition changes, one often has to change the column length and/or stationary phase, at least when something like optimum analytical conditions are needed. Temperature changes (or heating rates) can change the selectivity of a given column only within very limited ranges, due to the exponential effect of temperature on retention time. By serial coupling two chemically different capillaries, each run at another temperature, even the slightest changes of these two temperature values have a dramatic effect on the selectivity of the system for polar substances. We call this technique the SECAT mode of GC. Results are reported as retention index shifts, dependent on SECAT temperature data. This technique can in future easily be automated, thus enabling the analyst, for polar sample analysis, to adjust a given chroma-tographic system to his specific sample composition without touching the instrument.

Additional Material: 7 Ill.