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  • 1975-1979  (2)
  • Determination  (1)
  • Neurotoxic Esterase  (1)
  • 1
    Electronic Resource
    Electronic Resource
    Clinical and toxicological investigations of a case of delayed neuropathy in man after acute poisoning by an organophosphorus pesticide (1978)
    Springer
    Archives of toxicology 40 (1978), S. 279-284 
    Details
    ISSN: 1432-0738
    Keywords: Neuropathy ; Organophosphorus ; Trichlorphon ; Neurotoxic Esterase ; Screening
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Progressive neuropathy developed in a man during 2–8 weeks after acute poisoning by a pesticide said to contain trichlorphon. The neuropathy was typical of that caused by organophosphorus esters in the delay and in the maintenance of normal conduction velocity in surviving nerve fibres. A sample alleged to be typical of the ingested material was not more active against hen brain neurotoxic esterase (NTE) than was pure trichlorphon. Delayed neuropathy has never been produced in hens by a single dose of trichlorphon. This incident and studies of human brain in vitro suggest that the ratio neurotoxicity/lethality for trichlorphon is higher in man than in the hen. Suggestion is made of laboratory tests to improve neurotoxicity screening.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00310333
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Improved assay of neurotoxic esterase for screening organophosphates for delayed neurotoxicity potential (1977)
    Springer
    Archives of toxicology 37 (1977), S. 113-115 
    Details
    ISSN: 1432-0738
    Keywords: Determination ; Neurotoxic esterase ; Neurotoxicity ; Organophosphate compounds
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Description / Table of Contents: Zusammenfassung Durch Bestimmung der neurotoxischen Esterase (NTE) ist es möglich, im Gehirn von mit phosphororganischen Pflanzenschutzmitteln, Weichmachern und anderen Stoffen behandelten Hühnern die potentielle Neurotoxizität dieser Stoffe zu erfassen. Die ursprüngliche Methode [Johnson, M. K. Biochem. J. 114, 711–717 (1969)] wurde vereinfacht, so daß Zentrifugieren und Transferschritte nicht mehr erforderlich sind. Die Selektivität und Empfindlichkeit der Methode wurde verbessert. Die Herstellung stabiler Reagentienstammlösungen wird beschrieben.
    Notes: Abstract The assay of neurotoxic esterase (NTE) in brains taken from dosed hens enables potential neurotoxicity of organophosphate pesticides, plasticers, etc. to be assessed. The original assay [Johnson, M. K. Biochem. J. 114, 711–717 (1969)] has been simplified to eliminate centrifugation and transfer steps and both the selectivity and the sensitivity have been increased. The procedures necessary to obtain stable reagent stocks are described.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00293860
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
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