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Effect of alloxan on rat pancreatic polypeptide (PP) cells (1977)

Sundler, F. ; Håkanson, R. ; Lundquist, I. ; [et al.]

Springer

Cell & tissue research 178 (1977), S. 307-312

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ISSN: 1432-0878

Keywords: Pancreatic polypeptide (PP) cells ; Rat ; Effect of alloxan ; Experimental diabetes

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Medicine

Notes: Summary Injection of alloxan caused an almost total disappearance of insulin cells in the rat pancreas. Planimetric analysis revealed a 50 per cent reduction of the mean islet volume. The number of immunoreactive pancreatic polypeptide (PP) cells per sectioned islet was significantly increased, and the PP cell volume per islet doubled. Assuming an unchanged number of islets, the results indicate an increase in total PP cell mass following alloxan administration.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00218695

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