ISSN:
1432-0533
Keywords:
Acromegaly
;
Electron microscopy
;
Growth hormone
;
Pituitary adenoma
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Unusually large, oval and pleomorphic secretory granules were noted by electron microscopy in an acidophilic adenoma of the pituitary. The tumor, which was removed by surgery from a 42-year-old woman with elevated blood growth hormone levels and the clinical features of acromegaly, was found to contain growth hormone by the immunoperoxidase technique. This ultrastructural abnormality of secretory granules was not reported so far and was not seen among the 58 cases of growth hormone-producing adenomas investigated in our laboratory. The present case clearly shows that the cytogenesis and cellular composition of pituitary adenomas cannot be determined by solely examining the size and shape of secretory granules.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00690852
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