Electronic Resource
Springer
Naunyn-Schmiedeberg's archives of pharmacology
302 (1978), S. 61-62
ISSN:
1432-1912
Keywords:
Isolated guinea pig heart
;
Coronary vascular resistance
;
Myocardial force of contraction
;
Prostaglandin D2 (PGD2)
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary The action of prostaglandin D2 (PGD2) on myocardial force of contraction (MFC) and coronary vascular resistance (CVR) was studied in the isovolumetrically perfused guinea pig heart at constant driving frequency (180 beats/min). PGD2 (2·10−9–1·10−6 M) produced a concentration-dependent increase in the CVR while the MFC remained unchanged. The ED50 (50% of maximum response) of the coronary vasomotor action amounted to 4.3 ·10−8 M PGD2. The results give evidence for a potent coronary vasoconstrictor activity of PGD2.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00586598
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