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  • 1
    Electronic Resource
    Electronic Resource
    Effects of drug experience on drug induced conditioned taste aversions: Studies with amphetamine and fenfluramine (1975)
    Springer
    Psychopharmacology 44 (1975), S. 77-82 
    Details
    ISSN: 1432-2072
    Keywords: Conditioned Taste Aversions ; Amphetamine ; Fenfluramine ; Tolerance ; Cross-Tolerance ; Drug Abuse ; Animal Models
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Conditioned taste aversions (C.T.As) established in rats to 0.1% sodium saccharin by intra-peritoneal injections of dl-fenfluramine hydrochloride (6 mg per kg) or d-amphetamine sulphate (2.0 mg per kg) were found to be significantly attenuated, but not abolished altogether, by chronic pretreatment (over 9 days) with the specific drug. Prior treatment with fenfluramine attenuated the aversive effects of amphetamine, but the converse was found not to be the case. These results are considered to refute the “Unnatural need state” and “Novelty” hypotheses of the effects of prior drug experience on the establishment of C.T.As. An alternative explanation of such effects in terms of tolerance is considered, and the possible relevance of the results to studies of drug abuse in humans discussed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00421187
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Discriminative stimulus properties of fenfluramine in an operant task: An analysis of its cue function (1977)
    Springer
    Psychopharmacology 53 (1977), S. 97-102 
    Details
    ISSN: 1432-2072
    Keywords: Fenfluramine ; Norfenfluramine ; Amphetamine ; Drug discrimination ; Stimulus properties of drugs ; Fixed ratio responding
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Fenfluramine at a dose of 3.0 mg/kg was found to possess discriminative stimulus properties controlling lever selection by rats in a two-lever operant task. Subjects trained to discriminate the ‘Fenfluramine cue’ failed to generalize to amphetamine in extinction tests at doses between 0.25 and 1.0 mg/kg. Subjects did, however, generalize to the fenfluramine metabolite, norfenfluramine, at a dose of 2.0 mg/kg. These data provide further evidence for a pharmacological difference between fenfluramine and amphetamine, and support the hypothesis that norfenfluramine is an active metabolite of fenfluramine. The relevance of these findings to theoretical and methodological aspects of drug discrimination studies is considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00426700
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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