ISSN:
1612-1112
Keywords:
Pharmacokinetics
;
Metabolism
;
HPLC
;
Clanobutin
;
Lonazolac
;
Urapidil
Source:
Springer Online Journal Archives 1860-2000
Topics:
Chemistry and Pharmacology
Notes:
Summary The use of high-performance liquid chromatography in kinetics and metabolism studies is demonstrated. The following kinetic parameters are ascertained after single oral and intravenous administration of a drug: absorption by areal comparison, elimination constant in the β-phase, and clearance. Concentration levels in serum are measured after repeated oral administration on several days, with pharmacokinetic model fit to estimate limit concentrations in the steady state. Species-dependencies in metabolism are investigated in 24-h urines. The necessary characterization of drug and metabolite peaks is obtained by in-series connection of several detectors. The relative bioavailability of a controlled release form is determined by measuring drug concentrations in the blood.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF02259153
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