ISSN:
1432-0533
Keywords:
Pallidal atrophy
;
Centrum medianum
;
Spheroid
;
Akinesia
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary A 66-year-old man (case 1) and a 71-year-old woman (case 2) showed systemic degeneration of the globus pallidus, substancia nigra, subthalamic nucleus, centrum medianum thalami and at times, superior colliculus in the midbrain. In the pallido-nigral system, neuronal loss was severe in both cases and an increase of pigment and granular spheroids was marked in case 2, less in case 1. Electron-microscopilly, the spheroids consisted of aggregates of highly dense material, often membrane-bound, and varying amounts of groups of loosely packed filaments. Clinical symptoms were stereotyped and unique, showing severe akinesia, no rigidity in the limbs, no tremor but retropulsions, upward gaze palsy, dysarthria, dysphagia and later, nuchal stiffness. Nosological identification is discussed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00684546
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