ISSN:
1435-1463
Keywords:
Renin
;
dopamine-beta-hydroxylase
;
aldosterone
;
sodium
;
volume expansion
;
natriuresis
;
man
Source:
Springer Online Journal Archives 1860-2000
Topics:
Medicine
Notes:
Summary Circadian variations of plasma renin activity, plasma dopamine-beta-hydroxylase, and urinary aldosterone excretion were measured in man under conditions of high- and low-sodium intake. Plasma renin activity and urinary aldosterone excretion were maximal at 8 a.m. Plasma DBH shows small, biologically insignificant circadian fluctuations. In three subjects on low-salt diets, the values were lower than those in the same subjects on high-salt diets. Expansion of intravascular volume in supine normal volunteers lowered plasma renin and DBH activity, and also resulted in a significant natriuresis. The decline in DBH activity probably reflects a decrease in its release from autonomic nerve endings and thus demonstrates in man an effect of decreasing autonomic activity.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF01243427
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