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Digitale Medien

A COMPARISON BETWEEN FLUOROMETRIC AND MASS FRAGMENTOGRAPHIC DETERMINATIONS OF HOMOVANILLIC ACID AND 5-HYDROXYINDOLEACETIC ACID IN HUMAN CEREBROSPINAL FLUID (1978)

Sjöquist, Birgitta ; Johansson, Barbro

Oxford, UK : Blackwell Publishing Ltd

Journal of neurochemistry 31 (1978), S. 0

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ISSN: 1471-4159

Quelle: Blackwell Publishing Journal Backfiles 1879-2005

Thema: Medizin

Notizen: HVA and 5-HIAA in human cerebrospinal fluid were quantitatively determined by both fluorometry and mass fragmentography. The homovanillic acid values obtained by fluorometry were significantly lower than those obtained by mass fragmentography (P 〈 0.05). The correlation coefficient between values for HVA obtained by the two methods was high, r= 0.90. For 5-HIAA the concentrations obtained by the two methods were not significantly different while the correlation coefficient was lower, r= 0.55.

Materialart: Digitale Medien

URL: http://dx.doi.org/10.1111/j.1471-4159.1978.tb07833.x

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Digitale Medien

Analysis of tyrosine and deuterium labelled tyrosine in tissues and body fluids (1979)

Sjöquist, Birgitta

Chichester : Wiley-Blackwell

Biological Mass Spectrometry 6 (1979), S. 392-395

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ISSN: 0306-042X

Schlagwort(e): Chemistry ; Analytical Chemistry and Spectroscopy

Quelle: Wiley InterScience Backfile Collection 1832-2000

Thema: Chemie und Pharmazie

Notizen: A gas chromatographic mass spectrometric method has been developed to determine tyrosine and deuterium labelled tyrosine in biological samples using α-methyltyrosine (α-Me Ty) or m-hydroxyphenylalanine as internal standards. With the latter standard both labelled and unlabelled tyrosine as well as α-Me Ty can be determined simultaneously, in for example human blood, following administration of α-Me Ty to inhibit catecholamine synthesis. After isolation of the amino acids on an ion exchange column (Amberlite IR 120) the butyl ester pentafluoropropionyl derivatives were prepared. In human plasma the precision of the method was determined at a level of 80 nmol tyrosine ml-1 and found to be ±5% (coefficient of variation, n = 10).

Zusätzliches Material: 4 Ill.