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  • 1975-1979  (1)
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    Electronic Resource
    Electronic Resource
    Springer
    Psychopharmacology 45 (1975), S. 225-227 
    ISSN: 1432-2072
    Keywords: Plasma levels ; Nomifensine ; Kinetics ; Volunteers
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Nomifensine pharmacokinetics were determined in healthy volunteers after the oral administration of 50 mg of the drug. Peak plasma levels of 95-177 ng/ml were attained within 1 to 4 hrs, and the apparent plasma half-lives ranged from 3.3 to 4.9 hrs. Assuming 100% bioavailability the drug has a relatively large apparent volume of distribution. From these findings it appears that the pharmacokinetics profile of nomifensine is considerably different from those of other known antidepressants. Implications for dosages schedules are discussed.
    Type of Medium: Electronic Resource
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