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  • 1
    Electronic Resource
    Electronic Resource
    Cytostatic quinones. 3. Synthesis of benzotriazolequinones by a new oxidation with m-chloroperbenzoic acid. Biochemical studies (1978)
    s.l. : American Chemical Society
    Journal of medicinal chemistry 21 (1978), S. 578-582 
    Details
    ISSN: 1520-4804
    Source: ACS Legacy Archives
    Topics: Chemistry and Pharmacology
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1021/jm00204a014
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Halomethyl-1,2,3-triazole derivatives: A new type of alkylating agent active in mouse transplantable tumors (1978)
    Springer
    Cancer chemotherapy and pharmacology 1 (1978), S. 243-247 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A number of halomethyl-1,2,3-triazole derivatives have been tested for their effect on ICR Swiss female mice bearing the Ehrlich carcinoma ascites (ECA) tumor. Two of these compounds, namely 4-bromomethyl-1-(2,3,4,6-tetra-0-acetyl-β-D-glucopyranosyl)-1,2,3-triazole and 4-iodomethyl-1-(2,3,4,6-tetra-0-acetyl-β-D-glucopyranosyl)-1,2,3-triazole, referred to here as compounds H and K, respectively, promoted a significant increase in the median survival time (145% and 195%) when injected IP for 9 consecutive days at doses of 75 mg/kg/injection and 100 mg/kg/injection, respectively. DNA synthesis, as measured by (methyl-3H)thymidine incorporation into trichloroacetic acid-precipitated material, was always inhibited by all the triazole derivatives to a greater extent than the incorporation of (5,6-3H)uridine, (5-3H)proline, and (6-3H)-glucose. Moreover, inhibition of DNA synthesis was complete and irreversible following exposure to selected triazole derivatives. Compounds H and K inhibited the incorporation of di(3H)methyl sulfate by ECA cells. In addition, compound K promoted the release of radioactivity associated with trichloroacetic acid-insoluble material coming from (8-3H)guanosine-prelabeled cells. This release of radioactivity did not occur when cells were prelabeled with (methyl-3H)thymidine. It is concluded from these results that these triazole derivatives act as alkylating agents.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00257157
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  • 3
    Electronic Resource
    Electronic Resource
    Distances between populations ofDrosophila subobscura, based on chromosome arrangement frequencies (1975)
    Springer
    Theoretical and applied genetics 45 (1975), S. 231-241 
    Details
    ISSN: 1432-2242
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology
    Notes: Summary Distances between populations ofDrosophila subobscura, based on differences in the frequencies of chromosomal arrangements have been estimated using data from about 65 populations. The distances have been calculated using the formula: $$D = \frac{1}{{2r}}{\text{ }}\sum\limits_{j = 1}^r {\sum\limits_{k = 1}^{Sj} {|p_{1jk} - } p_{2jk} |} {\text{ }},$$ wherer is the number of loci or chromosomes (in the case of chromosomal polymorphism) considered,p 1jk the frequency of the allele or chromosomal arrangementk in the locus or chromosomej in the first population, andp zjk the corrsponding value in the second population. The main conclusion drawn from this analysis is that historical as well as adaptive factors are important in explaining the geographical distribution of chromosomal arrangements inD. subobscura. In general, isolated populations maintain primitive features in their chromosomal polymorphism. This is reflected in a tendency to similarity between these populations. Also, a very sharp effect of geographical barriers is detected in the distribution of the chromosomal arrangements. Two main factors are considered responsible for the strong effect that isolation has on geographical distribution of chromosome arrangements. These factors are the non-recurrence of rearrangements and the difficulty of establishing in one population the supergenes originated in another area, because of lack of coadaptation with the gene pool of the recipient population.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00831894
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  • 4
    Electronic Resource
    Electronic Resource
    The smooth endoplasmic reticulum in neurohypophysial axons of the rat: Possible involvement in transport, storage and release of neurosecretory material (1979)
    Springer
    Cell & tissue research 199 (1979), S. 415-429 
    Details
    ISSN: 1432-0878
    Keywords: Hypothalamo-neurohypophysial system (rat) ; Axoplasmic transport ; Smooth endoplasmic reticulum ; Neurosecretory granules ; Microvesicles
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The intra-axonal organization of the smooth endoplasmic reticulum was studied in the neurohypophysis of rats during and after water deprivation. Parallel to conventional electron microscopy, the material was treated with a double impregnation staining technique specifically designed to contrast the intracellular membranous system. In conventionally stained ultrathin sections from severely dehydrated rats most axons appeared to be free of membranous organelles, whereas corresponding axons treated with the double-impregnation technique generally exhibited a highly developed system of smooth endoplasmic reticulum. In axonal endings, both techniques revealed a profusion of microvesicles in intimate relationship with tubular elements of the smooth endoplasmic reticulum. In short-term (12 h) rehydrated rats, a similarly developed system of smooth endoplasmic reticulum was still observed at all axonal levels with both procedures. After 24 to 48 h of rehydration the tubules of the smooth endoplasmic reticulum exhibited, in double impregnated material, numerous dilatations which resembled the adjacent neurosecretory granules. In conventionally stained ultrathin sections, an accumulation of electron dense material occurred within tubules of the smooth endoplasmic reticulum in the more proximal axonal segments, while in the more terminal segments, which contained numerous elongated granules, membrane continuity was frequently observed between newly formed granules and the smooth endoplasmic reticulum. After 7 days of rehydration the general pattern of the axonal smooth endoplasmic reticulum was comparable to that in untreated rats. These results are discussed in the light of a suggested involvement of the axonal smooth endoplasmic reticulum in the non-granular transport of neurosecretory material in connection with (1) storage in distally formed granules, and (2) release via microvesicles.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236080
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Electron microscopic study of the orthograde axonal transport of horseradish peroxidase in the supraoptico-neurohypophysial tract of the rat (1978)
    Springer
    Cell & tissue research 194 (1978), S. 525-531 
    Details
    ISSN: 1432-0878
    Keywords: Hypothalamo-neurohypophysial tract ; Orthograde transport ; Horseradish peroxidase ; Smooth endoplasmic reticulum ; Neurosecretory granules ; Microvesicles
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary Horseradish peroxidase (HRP) has been used as a protein tracer in order to visualize the ultrastructural sites of the orthograde transport of protein macromolecules in the hypothalamo-neurohypophysial tract of the rat. After a local injection of HRP within the supraoptic nucleus, the reaction product was observed: (1) mainly in tubules of the smooth endoplasmic reticulum in the more proximal part of the axons, and (2) in granules and microvesicles of the axon terminals. Observations on thick sections clearly showed the existence of a relationship between the smooth endoplasmic reticulum containing HRP and the labeled granules or microvesicles. These data are in good agreement with previous findings showing the existence of direct continuity between tubules of the smooth endoplasmic reticulum and a fraction of the neurosecretory granules and microvesicles. This evidence further reinforces the hypothesis that the latter organelles may possibly originate locally in the axons from the tubules of the smooth endoplasmic reticulum which may therefore be proposed as a possible vehicle for a non-granular intra-axonal transport of neurosecretory material in neurosecretory neurons.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00236171
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    Paper (German National Licenses)
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