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  • 1
    Electronic Resource
    Electronic Resource
    Enhanced choice of familiar food in a food preference test after chlordiazepoxide administration (1978)
    Springer
    Psychopharmacology 59 (1978), S. 51-56 
    Details
    ISSN: 1432-2072
    Keywords: Chlordiazepoxide ; Feeding motivation ; Food preference ; Handling ; Novelty
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Chlordiazepoxide (5.0 and 10.0 mg/kg) increased the time spent eating familiar laboratory chow, in a food-choice test in which both familiar and novel food objects were available. Chlordiazepoxide did not affect the feeding response to the novel food. Prior handling of the rats and repeat testing affected feeding responses in the test, although in ways which were different from and independent of the effect of chlordiazepoxide. Chlordizepoxide may facilitate feeding responses by a direct enhancement of feeding motivation, and not necessarily secondarily by either a release of suppression of feeding or as attenuation of anxiety evoked by unfamiliarity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00428030
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Food and water intake in the non-deprived pigeon after chlordiazepoxide administration (1979)
    Springer
    Psychopharmacology 65 (1979), S. 99-101 
    Details
    ISSN: 1432-2072
    Keywords: Chlordiazepoxide ; Food and water intake ; Pigeon ; Sedation
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Food and water intake were measured in nondeprived pigeons over a 4h period during daytime. Under control conditions, the ratio of food to water intake was approximately 1:1, and both intakes were a simple linera function of time. Chlordiazepoxide (10 mg/kg, i.m.) doubled the mean amount of food intake, whilst leaving water intake unchanged. This is a first indication that chlordiazepoxide can selectively stimulate appetite for food in an avian species. Some birds showed sedation following a first acute injection; its duration was shortened after repeated injections, and the hyperphagic response to the drug was revealed.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00491987
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Water intake and time course of drinking after single or repeated chlordiazepoxide injections (1979)
    Springer
    Psychopharmacology 65 (1979), S. 191-195 
    Details
    ISSN: 1432-2072
    Keywords: Chlordiazepoxide ; Chronic administration ; Time-course of drinking ; Water intake
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Chlordiazepoxide (5.0, 10.0 or 15.0 mg/kg) was given to rats either acutely or for 9 consecutive days. Its effects were examined in a 15-min drinking test in which latency to drink, volume of water consumption and the time-course of drinking were measured. Chlordiazepoxide (10.0 mg/kg) produced the strongest stimulant effect on drinking and enhanced the frequency of occurrence of drinking both at the beginning and at the end of the test period. Chlordiazepoxide (15.0 mg/kg) delayed the onset of drinking and its peak effect was observed later than for other injection conditions. Single and repeated administration of chlordiazepoxide had the same effects on the measures taken in the test. Initial sedation to the drug treatment and subsequent tolerance to this effect were not, therefore, factors influencing the drug effects observed in this experiment. Possible mechanisms underlying the stimulation of drinking by chlordiazepoxide are considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433048
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Anaesthetisation of prefrontal cortex and response to noxious stimulation (1975)
    [s.l.] : Nature Publishing Group
    Nature 254 (1975), S. 439-440 
    Details
    ISSN: 1476-4687
    Source: Nature Archives 1869 - 2009
    Topics: Biology , Chemistry and Pharmacology , Medicine , Natural Sciences in General , Physics
    Notes: [Auszug] Following the bilateral injection of 1.0 ul 5% procaine hydrochloride (see legend to Fig. 1), the preinjection jump threshold of 0.86±0.22 mA (mean ± s.d.) was reduced to 0.77±0.19mA (/=6.2, P〈0.001), and after bilateral injection of 2 jil, it was further reduced to 0.73 ...
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1038/254439a0
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    Paper (German National Licenses)
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  • 5
    Electronic Resource
    Electronic Resource
    Feeding parameters with two food textures after chlordiazepoxide administration, alone or in combination with d-amphetamine or fenfluramine (1979)
    Springer
    Psychopharmacology 62 (1979), S. 253-259 
    Details
    ISSN: 1432-2072
    Keywords: d-Amphetamine ; Drug combinations ; Chlordiazepoxide ; Eating duration ; Eating rate ; Fenfluramine ; Food texture
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Chlordiazepoxide (5.0, 10.0 mg/kg) reduced the rate of eating and extended the duration of feeding in a 10 min feeding test. It also reduced the latency to feed. Both fenfluramine (1.0 mg/kg) and d-amphetamine (0.25 mg/kg) acted to reduce food intake, but by differing mechanisms. Fenfluramine reduced eating rate without affecting eating duration, whilst d-amphetamine reduced eating duration without reducing eating rate. The effects of chlordiazepoxide on feeding parameters were generally additive with those of either d-amphetamine or fenfluramine, whenever chlordiazepoxide was given in combination with one of the anorectic drugs. Food texture affected feeding behaviour; rats ate standard diet in pellet form faster than powdered food, although they spent longer eating the powdered food. Textural differences did not significantly interact with the changes in feeding responses induced by the 3 drugs, except that latency to eat after either d-amphetamine or fenfluramine injection, when pellets were available, was significantly prolonged. Characterising drug effects on feeding in terms of a 2-dimensional matrix of eating rate and duration is recommended, rather than relying solely on amount of food consumption as the measure of drug effects.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00431956
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    Paper (German National Licenses)
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  • 6
    Electronic Resource
    Electronic Resource
    Food-choice in a food-preference test: comparison of two mouse strains and the effects of chlordiazepoxide treatment (1979)
    Springer
    Psychopharmacology 65 (1979), S. 89-93 
    Details
    ISSN: 1432-2072
    Keywords: Chlordiazepoxide ; Familiar and novel foods ; Feeding motivation ; Food preference ; Mouse strains
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract In male mice of the C57 strain, chlordiazepoxide (CDP) (2.5, 5.0 and 10.0 mg/kg) reduced the latency to begin cating and prolonged the total time devoted to eating in a food-preference test. The increase in feeding duration arose from an increase in the mean duration of individual eating episodes and not from a change in the number of episodes that were initiated. In contrast, in male mice of the A2G strain CDP (at the same dose levels) did not reduce the latency to begin eating and only prolonged the total time devoted to cating at a single dose level (5.0 mg/kg). The two strains differed in their choice between novel and familiar foods that were concurrently available in the test. The A2G mice virtually ignored the palatable novel foods and devoted all their feeding to the familiar food. The C57 strain, however, spent more time eating the novel foods than the familiar food. CDP at all doses increased the duration of feeding devoted to familiar food in the C57 animals, but did not increase feeding duration in the A2G mice. However, CDP (10.0 mg/kg) increased the time spent eating novel foods in both strains to the same degree. Possible mechanisms underlying the effect of CDP on food-preference behaviour in mice and accounting for the strain difference in response to CDP are considered.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00491985
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  • 7
    Electronic Resource
    Electronic Resource
    Chlordiazepoxide-induced disruption of discrimination behaviour: A signal detection analysis (1979)
    Springer
    Psychopharmacology 63 (1979), S. 307-310 
    Details
    ISSN: 1432-2072
    Keywords: Chlordiazepoxide ; Signal detection analysis ; Conditioned discrimination ; Response disinhibition ; Rats
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract To assess the effects of chlordiazepoxide (CDP) on a stable discrimination performance, eight rats were trained on a simple brightness discrimination and injected with three dosages (0, 5, and 10 mg/kg) once performance was stable. Signal detection analysis of the results was used to differentiate sensory from motor/responsivity effects of the drug. At 5 mg/kg, CDP increased general responsiveness which is consistent with the hypothesis that CDP disinhibits responding. At 10 mg/kg, however, this effect on responsivity was reversed and there was also a suppression of stimulus sensitivity.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00433568
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    Paper (German National Licenses)
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  • 8
    Electronic Resource
    Electronic Resource
    Exploratory response habituation and the attenuating effect of an amphetamine-barbiturate mixture (1976)
    Springer
    Psychopharmacology 49 (1976), S. 91-96 
    Details
    ISSN: 1432-2072
    Keywords: dl-Amphetamine ; Amylobarbitone ; Drug mixture ; Habituation ; Exploratory response Light-onset reward ; Footshock
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Abstract Mutual potentiation between dl-amphetamine (0.75 mg/kg) and amylobarbitone (15.0 mg/kg) can occur, measured as a marked increase in locomotor exploratory responses in the rat (Rushton and Steinberg, 1963). Experiment 1 confirms the potentiation between amphetamine and amylobarbitone, and extends the finding to a distinctly different type of exploratory behaviour (the ‘head-poke’ response). However, the same amphetamine-barbiturate mixture did not affect the preference for responses rewarded by a light-onset contingency (Expt. 1), and also did not affect the threshold of a response elicited by aversive footshock (Expt. 2). The mixture may facilitate the occurrence of exploratory responses by a direct attenuation of the rate of habituation of the exploratory responses, and not secondarily by altering the reward or aversion of external stimuli, or by changing the animal's level of arousal.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00427477
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    Paper (German National Licenses)
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