ISSN:
1471-4159
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
The oral administration of an aminoacid mixture lacking tyrosine and phenylalanine induces, in rats, a profound depletion of tyrosine in serum and in brain. Brain tyrosine is maximally depleted by 73%, 2 h after treatment, when there is a concomitant decrease in the levels of HVA (by 50%), DOPAC (by 30%) and c-AMP (by 28%) in the basal ganglia. However, 4 to 8 h after treatment, when brain tyrosine is still depleted by 47 and 28%, respectively, DA metabolites and c-AMP levels have returned to normal. Our findings indicate that striatal tyrosine hydroxylase is fully saturated in v i m by the concentrations of tyrosine normally present in the basal ganglia. The results also suggest indirectly that decreased DA turnover results in decreased nerve activity, as judged by the decreased cyclic AMP levels.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1471-4159.1976.tb07014.x
Permalink