Library

X
feed icon rss

Your email was sent successfully. Check your inbox.

An error occurred while sending the email. Please try again.

Proceed reservation?

Export
  • 1
    Electronic Resource
    Electronic Resource
    Hematologic and histopathologic evaluation of N-(phosphonacetyl)-l-aspartate (PALA) in mice (1979)
    Springer
    Cancer chemotherapy and pharmacology 2 (1979), S. 183-187 
    Details
    ISSN: 1432-0843
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The study reported here was designed to provide a preliminary indication of the qualitative and quantitative toxicity of N-(phosphonacetyl)-l-aspartate (PALA). PALA was administered IP to male B6D2F1 mice (22–24 g) daily for 9 days in dosages of 180, 220, and 290 mg/kg. These dosages were chosen to approximate 0.8 LD10, LD10, and LD50, based on historical 30-day lethality data. Five mice from each dosage group were killed on days 6, 10, 16, and 30 (day of first treatment = day 1) for hematologic and histopathologic evaluation. Only minimal changes were detected in peripheral hematologic values. PALA produced reticulocytopenia with a nadir on day 10(24 h after last treatment). Reticulocyte counts were only marginally reduced by 180 mg/kg/day; nadirs were 33% and 23% of control following 220 and 290 mg/kg/day. Lymphopenia was observed on day 10, but it was not as severe in survivors of 290 mg/kg as it was in recipients of the lower dosages. Thrombocytopenia was not observed, and total marrow cell counts did not reflect hematotoxicity. Peripheral hematology was normal in survivors of 180 and 220 mg/kg/day by day 16. Reticulocytopenia in survivors of 290 mg/kg/day persisted, however, and no survivors of this dosage were available for assessment of recovery on day 30. Mild, diffuse hypertrophy of the gastrointestinal epithelium was the most consistent lesion observed. These lesions were most evident on day 10, and they were comparable in severity across the dosage range studied. The mice treated with 180 mg/kg/day exhibited no evidence of gastrointestinal toxicity on day 16; survivors of 220 and 290 mg/kg/day had residual lesions that generally were less severe than on day 10, although the effects of 290 mg/kg were more distinct. No survivors exhibited lesions on day 30. These results suggest that gastrointestinal toxicity may be dose-limiting, but, unlike most other anticancer drugs of the antimetabolite class, PALA may be only mildly hematotoxic.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00258293
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 2
    Electronic Resource
    Electronic Resource
    Diazepam actions and plasma concentrations following ethanol ingestion (1977)
    Springer
    European journal of clinical pharmacology 11 (1977), S. 345-349 
    Details
    ISSN: 1432-1041
    Keywords: Diazepam ; ethanol ; plasma levels ; interaction ; motor performance
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary In eight normal volunteers, the combination of ethanol (0.5 g/kg) and diazepam (10 mg) administered orally produced a greater decrease in motor performance on a pursuit rotor than diazepam alone. The pharmacologic effect of diazepam was enhanced by 73% and this potentiation was associated with significantly greater diazepam concentrations (p〈0.01) than after diazepam alone. The failure to observe any increase in the concentrations of the principal metabolite, N-desmethyl diazepam, during the period of enhanced pharmacologic effect precludes any change in the demethylating metabolic process as being responsible. The data suggest (0.10〉p〉0.05) a trend to a smaller volume of distribution of diazepam when ethanol is administered prior to diazepam ingestion. The subjects showed acute tolerance to the effects of diazepam. Lower plasma concentrations on the ascending side of the plasma diazepam concentration versus time profile were linked with the same pharmacologic responses associated with a greater drug concentration on the descending portion, of the same curve.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00566531
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 3
    Electronic Resource
    Electronic Resource
    Absorption of oral and intramuscular chlordiazepoxide (1978)
    Springer
    European journal of clinical pharmacology 13 (1978), S. 267-274 
    Details
    ISSN: 1432-1041
    Keywords: Chlordiazepoxide ; benzodiazepines ; pharmacokinetics ; bioavailability ; intramuscular injection ; alcohol withdrawal
    Source: Springer Online Journal Archives 1860-2000
    Topics: Chemistry and Pharmacology , Medicine
    Notes: Summary The absorption of oral and intramuscular (i. m.) chlordiazepoxide hydrochloride (CDX · HCl) was compared in two pharmacokinetic studies. In Study One, single 50-mg doses of CDX · HCl were administered orally and by i. m. injection to 14 healthy volunteers using a crossover design. Whole-blood concentrations of chlordiazepoxide (CDX) and its first active metabolite, desmethylchlordiazepoxide (DMCDX), were determined in multiple samples drawn after the dose. Mean pharmacokinetic variables for CDX following oral and i. m. administration, respectively, were: highest measured blood concentration, 1.65 vs 0.87 µg/ml (p〈0.001); time of highest concentration, 2.3 vs 7.6 h after dosing (p〈0.001); apparent absorption half-life, 0.71 vs 3.39 h (p〈0.001). Biphasic absorption after i. m. injection, consistent with precipitation at the injection site, was observed in 9 of 14 subjects. Based upon comparison with previous intravenous data, the completeness of absorption was 100% for oral vs 86% for i. m. CDX · HCl (p〈0.1). In Study Two, 28 male chronic alcoholics with clinical manifestations of the acute alcohol withdrawal syndrome were randomly assigned to one of four treatment conditions: 50 or 100 mg doses of CDX · HCl, by mouth or by i. m. injection. Concentrations of CDX and DMCDX, determined in plasma samples drawn every 20 min for 5 h following the dose, were significantly higher after oral administration of a given dose than at corresponding points in time after i.m. injection after the same dose. Thus absorption of oral CDX is reasonably rapid and complete, whereas the absorption rate of i. m. CDX is slow.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00716362
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
  • 4
    Electronic Resource
    Electronic Resource
    The X-ray fluorescence analysis of ferronibium by a fusion method (1978)
    New York, NY [u.a.] : Wiley-Blackwell
    X-Ray Spectrometry 7 (1978), S. 2-4 
    Details
    ISSN: 0049-8246
    Keywords: Chemistry ; Analytical Chemistry and Spectroscopy
    Source: Wiley InterScience Backfile Collection 1832-2000
    Topics: Physics
    Notes: An X-ray method has been developed for the routine determination of niobium, tantalum and residual elements inferrniobium. The sample is pre-ooxidized and fuded in a misture of lanthanum oxide and lithium tetraborate. Calibration is by synthetic standards; molybdenum is added as internal standard for niobium, and corrections are applied for interferences on tantalum.
    Additional Material: 2 Ill.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1002/xrs.1300070103
    Library Location Call Number Volume/Issue/Year Availability
    BibTip Others were also interested in ...
    Paper (German National Licenses)
    Fulltext
Close ⊗
This website uses cookies and the analysis tool Matomo. More information can be found here...