ISSN:
1471-4159
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
The increase in the release of acetylcholine (ACh) from cortical slices of rat brain elicited by the depolarizing agents, ouabain and tityustoxin (TsTX) was compared in the presence of tetrodotoxin, an inhibitor of Na+ transport and of ethyleneglycol tetraacetic acid, a specific chelator of Ca2+. TsTX stimulated the release of ACh independently of K1 but required both Na+ and Ca2+. Unlike ouabain, TsTX failed to inhibit the Na+, K+ -ATPase of rat brain homogenates. The uptake of 24Na+ and of 45Ca2+ by the slices was significantly enhanced by TsTX over the entire incubation period during which this process was compared to TsTX-free controls. A hypothesis of TsTX action is proposed which differs from that necessary to explain the ACh releasing effect of ouabain.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1471-4159.1975.tb11884.x
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