ISSN:
1432-1203
Source:
Springer Online Journal Archives 1860-2000
Topics:
Biology
,
Medicine
Notes:
Summary Two double heterozygous β0/δβ0 thalassemic sibs of Mexican descent were studied. The father had a β0/β0 genotype, while the mother, one sib and several maternal relatives were β0/δβ0 heterozygotes. Parental consanguinity and an apparently low frequency of thalassemia among Mexicans suggested a possible common origin of both β0 and δβ0 genes. A hypothesis to explain such a possibility is proposed on the basis of a partial mispairing between β0 and δ genes followed by a crossing-over which would results in a δβ0 recombinant gene. This hypothesis could also be extended to explain the β 22 glu→ala, δ 22 ala→glu and δ 116 arg→his Hb variants as recombinants from double crossing-over between β and δ mispaired genes for which the name “interstitial-Lepore” is proposed.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1007/BF00277642
Permalink