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  • 1
    Electronic Resource
    Electronic Resource
    DECREASED AXONAL FLUX OF RETROGRADELY TRANSPORTED GLYCOPROTEINS IN EARLY EXPERIMENTAL DIABETES (1979)
    Oxford, UK : Blackwell Publishing Ltd
    Journal of neurochemistry 33 (1979), S. 0 
    Details
    ISSN: 1471-4159
    Source: Blackwell Publishing Journal Backfiles 1879-2005
    Topics: Medicine
    Notes: Abstract— Anterograde and retrograde flux of axonal transported glycoproteins were examined in streptozotocin diabetic rats with 4 weeks’duration of the metabolic derangement.[3H]Fucose and [14C]NeuNAc were injected into the fifth lumbar root ganglion and the accumulation of TCA-PTA insoluble activity proximal and distal to a sciatic nerve ligature was measured.Accumulation of glycoproteins during 2 h collection periods was decreased distal to a ligature in diabetic animals whereas no abnormality of proximal accumulation was observed. These findings demonstrate an abnormality of the retrograde transport of glycoproteins in early experimental diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1111/j.1471-4159.1979.tb05241.x
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Axonal dwindling in early experimental diabetes. II. A study of isolated nerve fibres (1976)
    Springer
    Diabetologia 12 (1976), S. 547-553 
    Details
    ISSN: 1432-0428
    Keywords: Streptozotocin diabetes ; myelinated nerve fibres ; nerve degeneration ; diabetic neuropathy
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary In a morphometric study of isolated fibres of the common peroneal nerve in short-term diabetic rats reduced fibre calibre was observed. No segmental demyelination or remyelination was found, but the nodes of Ranvier were slightly widened and paranodal bulbi were swollen relative to fibre calibre. It is suggested that axonal dwindling is the primary event in experimental diabetes. The reduction of the myelin sheath may be a consequence of the abnormal nerve cell offshoot. The results obtained suggest that streptozotocin diabetes in the rat is a useful model for the elucidation of diabetic neuropathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01220630
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Axonal dwindling in early experimental diabetes. I. A study of cross sectioned nerves (1976)
    Springer
    Diabetologia 12 (1976), S. 539-546 
    Details
    ISSN: 1432-0428
    Keywords: Streptozotocin diabetes ; axons ; myelin sheath ; nerve degeneration ; neural conduction
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary A diminution of the cross sectional area of myelinated fibres in the common peroneal nerve was observed in rats four weeks after the induction of diabetes with streptozotocin. Small fibres were affected more than larger ones and the axon reduction was twice that of the myelin sheath. The fibre diminution and the decreased axon/myelin ratio may explain the slowing of nerve conduction in experimental diabetes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01220629
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    Peripheral nerves in early experimental diabetes (1978)
    Springer
    Diabetologia 14 (1978), S. 113-119 
    Details
    ISSN: 1432-0428
    Keywords: Streptozotocin diabetes ; diabetic neuropathy ; peripheral nerves ; ultrastructure ; Schwann cells ; endoneurium
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The aim of the present study was to examine whether the nerve water content and the Schwann cell cytoplasm are increased in early experimental diabetes, as suggested in the sorbitol theory. The sciatic nerves of streptozotocin diabetic rats were found to have an increased wet weight. The amount of Schwann cell cytoplasm was reduced by 30%. The increased wet weight was paralleled by enlargement of the cross sectional area of the nerve which was explained by an expansion of the endoneurial space. The findings indicate the existence of endoneurial oedema and are in part in conflict with the sorbitol theory. Extension of the space surrounding the nerve fibres may explain the increased resistance to ischaemia in diabetic patients.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01263449
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    Paper (German National Licenses)
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