ISSN:
1440-1681
Source:
Blackwell Publishing Journal Backfiles 1879-2005
Topics:
Medicine
Notes:
1. In urethane anaesthetized sham-operated rats, intravenous administration of Δ1-THC (1 mg/kg) caused an immediate and prolonged fall in blood pressure, with a concomitant reduction in pulse rate.2. In rats which had been adrenalectomized 24 h previously, Δ1-THC (1 mg/kg, i.v.) also caused a depressor response, but it was significantly shorter in duration than that observed in sham-operated animals. The durations of the cardiac slowing effect were similar in both groups of rats.3. Hydrocortisone pretreatment (25 μg/kg〉 i-v), given 45 min before Δ1-THC, restored the duration of the depressor response to Δ1-THC in adrenalectomized rats, but it did not have any effect on the bradycardia induced by Δ-THC.4. Hydrocortisone did not produce any significant effect on the hypotensive action of Δ1-THC in sham-operated rats, but the cardiac slowing effect was markedly potentiated.5. These results suggest a lack of correlation between the hypotensive and cardiac slowing actions of the drug and that a certein level of adrenal steroids is necessary for the maintenance of the depressor response to Δ1-THC.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1111/j.1440-1681.1978.tb00673.x
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