ISSN:
0018-019X
Keywords:
Chemistry
;
Organic Chemistry
Source:
Wiley InterScience Backfile Collection 1832-2000
Topics:
Chemistry and Pharmacology
Notes:
Search for Antiviral Nucleosides AnaloguesIn contrast to the reported impossibility of obtaining the expected products when 1-(2,3-O-isopropylidene-1,5-dialdoribofurannos-1-yl)uracile (2) was treated with stabilized ylides, we prepared in good to excellent yields the modified nucleosides 4-9 by reaction of 2 respectively with acetylmethylidene-, benzoylmethylidene-, ethoxymethylidene-, methoxymethylidene-, succinimidylidene- or N-phenylsuccinimidylidene-triphenylphosphorane. Compounds 4-10 were tested against the herpes virus type 1 (HF) and influenza virus A2/Scotland. The modified nucleoside 9 showed a limited but significative activity against the herpes virus.
Type of Medium:
Electronic Resource
URL:
http://dx.doi.org/10.1002/hlca.19790620828
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