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Two-nucleotide codon change in a hemoglobin polymorphism of the Celebes black ape (Macaca nigra) (1976)

Murata, Mitsuo ; Thompson, Peter E.

Springer

Biochemical genetics 14 (1976), S. 183-195

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ISSN: 1573-4927

Keywords: hemoglobin ; polymorphism ; macaque ; codon ; mutation

Source: Springer Online Journal Archives 1860-2000

Topics: Biology , Chemistry and Pharmacology

Notes: Abstract A hemoglobin polymorphism involving variant β-chains was demonstrated in the Celebes black ape, Macaca nigra. Fingerprinting and amino acid analysis of the tryptic peptides from the two chain types have shown that they differ by a single amino acid substitution, between lysine and aspartic acid, which requires a two-nucleotide change in the corresponding codon. Another substitution in the same codon is found as a species difference between the black ape β-chain and that of other macaques.

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1007/BF00484883

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