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  • 1
    Electronic Resource
    Electronic Resource
    Evidence for the presence of viable endothelial cells in cultures derived from dissociated rat brain (1978)
    Springer
    Cellular and molecular life sciences 34 (1978), S. 95-97 
    Details
    ISSN: 1420-9071
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The morphology and histochemistry of dissociated newborn rat brain was studied in tissue culture. Direct microscopy of developing cells, electron microscopy and the alkaline phosphatase activity were used to identify the capillary endothelial cells.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF01921925
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Fluorescence histochemical observations on the distribution of exogenous dihydroisoquinoline in the rat brain (1979)
    Springer
    Experimental brain research 34 (1979), S. 155-164 
    Details
    ISSN: 1432-1106
    Keywords: Isoquinolines ; Rat brain ; Blood brain barrier ; Fluorescence histochemistry
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary The distribution of fluorescence in the rat brain after i.p. or intracerebral (i.c.) injections of a fluorescent dihydroisoquinoline derivate of dopamine was studied. After low i.p. doses (50 mg/kg of body weight) the fluorescence was totally confined to the capillary endothelial cells in the cerebral cortex, neostriatum, and substantia nigra (SN). After large i.p. doses (500 mg/kg) fluorescent material was also present in the neuropil of all the regions studied and some cells of the cerebral cortex and SN. After injections to the neostriatum or SN fluorescence was observed in the endothelial cells and some small to medium-sized rounded cells in both regions. A conspicious dark area contrasting with the background fluorescence was constantly present around capillaries, and this area was in contact with nonfluorescent multibranched cells of astrocytic type. In fluorescent cells the fluorescence was present both in the cytoplasm and the nucleus.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00238348
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    Paper (German National Licenses)
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  • 3
    Electronic Resource
    Electronic Resource
    Experimental alcoholic neuropathy in the rat: Histological and electrophysiological study on the myoneural junctions and the peripheral nerves (1978)
    Springer
    Acta neuropathologica 41 (1978), S. 131-137 
    Details
    ISSN: 1432-0533
    Keywords: Alcohol ; Polyneuropathy ; Rat peripheral nerve ; Electron microscopy ; Cholinesterases ; Electrophysiology
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Peripheral nerves and myoneural junctions of the tibialis anterior muscle of the rat were studied histologically and electrophysiologically after various periods of peroral ethanol treatment. Histochemical distributions of non-specific cholinesterase (ns. ChE; E.C. 3.1.1.8) and acetylcholinesterase (AChE; E.C. 3.1.1.7) activity of the muscle were normal during the first 3 months of daily ethanol drinking. After 5 months of exposure to 10–25% (v/v) ethanol as the sole drinking fluid, pathological ns. ChE activity was seen sporadically along the intramuscular nerves with slight ultrastructural changes in the Schwann cells. After 7 months of ethanol treatment there was further increased pathological ns. ChE activity in the intramuscular nerves while the AChE activity remained normal in the muscle. More prominent ultrastructural changes were seen in the Schwann cells namely swelling and vacuolization of the cytoplasm and dilatation of the rough endoplasmic reticulum. Increased numbers of small axons were also seen. After 9.5 months on alcohol marked increase in the ns. ChE activity was observed along most of the intramuscular nerves. AChE activity of the myoneural junctions was only sporadically weakened. A slight slow-down in the conduction velocity of the large myelinated size A fibers was observed in the animals on alcohol from 7–9.5 months, whereas the conduction velocity of the smaller myelinated B fibers was not appreciably changed. The present experiment indicates that progressive neuropathy can be induced in rats by oral alcohol feeding along with the normal laboratory diet. The first pathological changes were seen in the Schwann cells and could well be followed by the methods employed. The present experimental model can possibly be used in future studies concerning the development of toxic polyneuropathy.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00689764
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    Paper (German National Licenses)
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  • 4
    Electronic Resource
    Electronic Resource
    The development of histochemically demonstrable cholinesterases in the rat neostriatum in vivo and in vitro (1979)
    Springer
    Histochemistry and cell biology 64 (1979), S. 35-50 
    Details
    ISSN: 1432-119X
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Summary The development of acetylcholinesterase (AChE) and non-specific cholinesterase (NsChE) activity was studied in the rat neostriatum by the light and electron microscope using three thiocholine methods. The AChE activity was first demonstrable only in the lateral parts of the nucleus, and during the early postnatal development the most intense activity was in the cell bodies, whilst the typical intense staining of the neuropil of adult animals was seen in two-week-old rats. Two types of AChE-containing cells were observed in the neostriatum of rats younger than two weeks and in cultures of newborn rat neostriatal cells. The neuropil of the cultures showed weak activity in the membranes of thin preterminal processes. In the neuropil of old rats, NsChE activity was present in the membranes of nerve cell processes. The capillary endothelial cells of newborn rats contained both AChE and NsChE. During subsequent development, the AChE activity disappeared, whilst for NsChE no change was seen in the distribution of activity seen in newborn or young adult rats less than three months old.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00493353
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    Paper (German National Licenses)
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