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  • 1
    Electronic Resource
    Electronic Resource
    Antifibrin action of phenformin (1975)
    Springer
    Diabetologia 11 (1975), S. 105-111 
    Details
    ISSN: 1432-0428
    Keywords: Thrombin time ; thrombin-fibrinogen reaction ; fibrinolytic activity ; plasminogen activator ; phenformin ; antifibrinopathic action ; lipid lowering effect ; hypoglycaemic effect ; plasma insulin clearance ; serum triglyceride ; euglobulin clot lysis time ; inter-relationship between hypoglycaemic and antifibrinopathic effect ; slow consumptive fibrinocoagulopathy ; fibrinocoagulopathic pathogenesis
    Source: Springer Online Journal Archives 1860-2000
    Topics: Medicine
    Notes: Summary Effects of phenformin on blood sugar, serum triglyceride, thrombin time, euglobulin clot lysis time and cardiovascular complications were studied in maturity onset diabetics and in atherosclerotic patients with or without diabetes, for a period of 14–18 months. Phenformin has shown the characteristic properties of an antifibrinopathic agent in that it prolongs thrombin time and enhances fibrinolysis. The hypoglycaemic effect of phenformin was found to be directly related to its antifibrinopathic action. Plasma lipids fell in all cases. Absence of fresh cardiovascular complications and improvement in anginal symptoms were observed. The metabolic, haematological and clinical benefits of phenformin and its limitations in maturity onset diabetes and atherosclerosis may be explained by the effects of the drug upon the thrombin-fibrinogen reaction. These results lend support to the hypothesis of a primary fibrinopathic pathogenesis in maturity onset diabetes mellitus and atherosclerosis.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00429832
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    Paper (German National Licenses)
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  • 2
    Electronic Resource
    Electronic Resource
    Insect sex chromosomes (1979)
    Springer
    Chromosoma 74 (1979), S. 241-252 
    Details
    ISSN: 1432-0886
    Source: Springer Online Journal Archives 1860-2000
    Topics: Biology , Medicine
    Notes: Abstract A presumptive mechanism of X inactivation has been investigated by using tritiated uridine-induced chromosome aberrations to distinguish active from inactive X chromosome arms in the insect Gryllotalpa fossor. Previous work on therian mammals has shown that constitutive and facultative heterochromatin are less susceptible to breakage by 3H-Urd than euchromatin (active). The present study indicates that, irrespective of the presence of two X chromosomes in females, only one of these is affected as in males and that the total number of aberrations induced by 3H-Urd in both male and female Gryllotalpa is the same. This suggests that in the female only one arm of one X chromosome is active and that a facultative heterochromatinization of the homologous arm of the other X is operative coupled with the presence of constitutive heterochromatin in the second arm of both X chromosomes.
    Type of Medium: Electronic Resource
    URL: http://dx.doi.org/10.1007/BF00292275
    Library Location Call Number Volume/Issue/Year Availability
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    Paper (German National Licenses)
    Fulltext
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