ZIB

Hits per page

hits 1 - 2 | 2 hits

Sorting

Electronic Resource

Structures of norditerpene lactones from Podocarpus species (1976)

Arora, Satish K. ; Bates, Robert B. ; Chou, Paul C. C. ; [et al.]

s.l. : American Chemical Society

The @journal of organic chemistry 41 (1976), S. 2458-2461

add to mindlist on the mindlist

Details

ISSN: 1520-6904

Source: ACS Legacy Archives

Topics: Chemistry and Pharmacology

Type of Medium: Electronic Resource

URL: http://dx.doi.org/10.1021/jo00876a023

Permalink

Library	Location	Call Number	Volume/Issue/Year	Availability

Others were also interested in ...

Paper (German National Licenses)

Fulltext

Electronic Resource

Genetics and biochemistry of cryptopleurine resistance in the yeast Saccharomyces cerevisiae (1977)

Sánchez, L. ; Vásquez, D. ; Jiménez, A.

Springer

Molecular genetics and genomics 156 (1977), S. 319-326

add to mindlist on the mindlist

Details

ISSN: 1617-4623

Source: Springer Online Journal Archives 1860-2000

Topics: Biology

Notes: Summary Protein synthesis by ribosomes from several cryptopleurine-resistant yeast mutants is also resistant to emetine and tubulosine. These mutants can be classified into two different types: Class I mutants which display high levels of resistance to emetine and tubulosine and Class II mutants that are only weakly resistant to tubulosine and are slightly more sensitive to emetine than those of Class I. Apparently all mutants have similar levels of resistance to cryptopleurine. The distinct phenotypes of Class I and Class II strains are expressed through their 40S ribosomal subunit. Genetic analysis has shown that the mutations to cryptopleurine resistance are allelic and that in a particular case (strain CRY6) the pleiotropic phenotype is a result of the expression of the cryl locus. It is suggested that Class I and Class II mutants arise from two independent mutational events within the cryl allele. in heterozygous (+/cryl) diploids both the sensitive and the resistant genes are expressed as shown by studies of the action of cryptopleurine on polyphenylalanine-synthesizing system derived from each parental sensitive and resistant haploid strain and heterozygous diploid strains. The apparent dominance of sensitivity over resistance which may be observed in vivo in heterozygous (+/cryl) diploids has been explained in terms of the mode of action of the inhibitors.